SERPINF1

SERPINF1

A gene on chromosome 17p13.3 that encodes a member of the serine protease inhibitor (serpin) family. SERPINF1 does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins; it has no serine protease inhibitory activity, but it inhibits angiogenesis and is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.
Mentioned in ?
References in periodicals archive ?
The gene panel contains all reported genes related to OI (COL1A1, COL1A2, IFITM5, SERPINF1, CRTAP, LEPRE1, PPIB, SERPINH1, FKBP10, PLOD2, BMP1, C-propeptide cleavage site, SP7/OXS, WNT1, TMEM38B, CREBL1, and PLS3).
For example, the following genes exhibited statistically significant (P<05) modulation early in Zone I and late in Zone II: CDH5, PECAM-1, SERPINF1, TGFBR1, Endothelial cell growth factor-1 (Ecgfl), Endothelial PAS domain protein-1 (Epasl), Epiregulin (Ereg), Interleukin 12a (1112a), Integrin aV (Itgav), Nudix-type motif 6n (Nudt6), and Tumor necrosis factor ligand superfamily member-12 (Tnfsfl2).
Although OI-3 is rare, studies in affected persons from different parts of the world have revealed causative mutations in several genes: CRTAP, P3H1, FKBP10, PPIB, SERPINH1, SERPINF1, BMP1, SP7, WNT1, TMEM38B, PLOD2 and CREB3L1.
In addition, the hsa-mir-200c was associated with the IGFBP7, PDLIM3, and SERPINF1 expression.
For the SID-MRM analysis, we first synthesized stable-isotope standard (SIS) peptides (>95% purity) for 15 proteins (APLP2, APOA4, APOH, B3GNT1, C4B, C5, C7, CD14, CLU, FN1, GSN, ITIH2, KRT1, SERPINF1, and VTN).
(7) Other genes, such as ASTN2 and SERPINF1, have been associated with increased risk of lung adenocarcinoma in never-smokers.
Machann et al., "Common genetic variation in the SERPINF1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels," PLoS ONE, vol.
Pigment epithelium-derived factor (PEDF), also known as serpin F1 (SERPINF1), is a multifunctional secreted protein that has antiangiogenic, antitumorigenic, and neurotrophic functions.
Uromodulin, SERPINF1 (serpin peptidase inhibitor, clade F, [alpha]-2 antiplasmin, pigment epithelium derived factor, member 1), and CD44 were verified in an independent cohort and shown to differentiate patients with AR from other groups.
Pigment epithelium-derived factor (PEDF), also known as Serpin F1 (SERPINF1), was originally isolated from human fetal retinal pigment epithelial cells and was defined as a potent antiangiogenic factor [1, 2].
In contrast, genes involved in stem cell maintenance, such as cell adhesion molecules, WNT, and Notch-signaling pathway components, CDH1, SERPINF1, LEF1, FRZB1, KRT19, SOD2, and EGR1, were overexpressed in the limbal crypt [44].
[12] Human genes: VWF, von Willebrand factor; LEP, leptin; MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); FBLN1, fibulin 1; FBLN2, fibulin 2; ACTS, actin, beta; CRISPLD2, Cysteine-rich secretory protein LCCL domain containing 2; SERPINF1, Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; ITM2A, Integral membrane protein 2A; LEPR, leptin receptor; ZFP36L2, zinc finger protein 36, C3H type-like 2; ELN, elastin.