SERPINE2


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Related to SERPINE2: PubMed, SLPI

SERPINE2

A gene on chromosome 2q33-q35 that encodes a serine protease inhibitor that acts on thrombin, trypsin and urokinase; it promotes neurite extension by inhibiting thrombin.
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One of the better known and more studied members of serpin superfamily is SERPINE2 (serpin peptidase inhibitor clade E member 2), also known as protease nexin-1 (PN-1).
SERPINE2 and SLPI have also been postulated as new molecular targets in the therapy of certain cancers [22-25].
However, the mechanism responsible for the elevated serum concentration of SERPINE2 and SLPI in PTC patients remains unknown and further experiments are hence necessary to clearly identify the molecular mechanisms associated with SERPINE2 and SLPI during the morphological transformation between human normal thyroid epithelial cells and neoplasms.
Our findings indicate that the estimation of SERPINE2 and SLPI serum concentration may allow the preoperative differentiation of malignant and benign tumors of the thyroid gland.
Durand et al., "The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis," Molecular Cancer, vol.
Yu, "Prognostic significance of SERPINE2 in gastric cancer and its biological function in SGC7901 cells," Journal of Cancer Research and Clinical Oncology, vol.
Wu, "Serpine2, a potential novel target for combating melanoma metastasis," American Journal of Translational Research, vol.
Oka et al., "SERPINE2 is a possible candidate promotor for lymph node metastasis in testicular cancer," Biochemical and Biophysical Research Communications, vol.