SERPINE1

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
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Subsequent studies failed to demonstrate the presence of a putative fusion gene until 2014, when Walther et al, (19) using cytogenetics, fluorescence in situ hybridization, messenger RNA sequencing, and real-time polymerase chain reaction, demonstrated a balanced t(7;19)(q22;q13) translocation resulting in the fusion of the SERPINE1 and FOSB genes in several cases.
TGF-[beta] signaling marker SERPINE1 was significantly induced by recombinant TGF-[beta], indicating that active TGF-[beta] signaling was induced in the micromasses (Fig.
Plasminogen activator inhibitor-1 (PAI-1), encoded by SERPINE1, is a specific inhibitory member of plasminogen activation (PA) system.[15] Except for its key role in acute thrombotic events, PAI-1 was also expected to prevent cancer invasion and metastasis through its inhibition of urokinase-type plasminogen activator, which was demonstrated to be involved in malignant dissemination.[15] Indeed, there were some published articles showing this metastasis inhibitory effect.[16],[17],[18] However, more articles suggested its pro-oncogenic roles.[19],[20],[21],[22],[23],[24] In PC/PDAC, different in vitro and in vivo experiments also got inconsistent, even opposite results.[17],[19],[23] However, those for its prognostic significance in PDAC seem to be more consistent.
Metadichol[R] besides of TNF alpha inhibitor also inhibits Plasminogen Activation Inhibitor (PAI1) also known as SERPINE1. The above genes play a vital role in diabetes.
Specific gene expression was measured with the following Taqman assays (Life Technologies): C3 (Mm01232779_m1, C3), procollagen 3a1, (Mm01254476_m1, Col3a1), Fibronectin (Mm01256744_m1, Fn1), and PAI-1 (Mm00435858_m1, Serpine1).
A network of transcription factors jun (JUN), leptin (LEP), serpin peptidase inhibitor E type 1 (SERPINE1), apolipoprotein E (APOE), and peroxisome proliferator-activated receptor gamma (PPARG) was examined to identify their potential relationship (Figure 2).
We measured blood levels of 10 cytokines including 6 pro-inflammatory cytokines [interleukin-1 (IL-1; gene name: IL1), interleukin-6 (IL-6; gene name: IL6), tumor necrosis factor-[alpha] (TNF-[alpha]; gene name: TNF), toll-like receptor-2 (TLR-2; gene name: TLR2), CD40 ligand (CD40L; gene name: CD40LG), and intercellular adhesion molecule-1 (ICAM-1; gene name: ICAM1)], two procoagulant cytokines [tissue factor (F3; gene name: F3) and plasminogen activator inhibitor-1 (PAI-1; gene name: SERPINE1)], and two vasoconstrictors [endothelin-1 (ET-1; gene name: EDN1) and angiotensin converting enzyme-1 (ACE-1; gene name: ACE)].
Yesilkaya et al., "Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome," Journal of Assisted Reproduction and Genetics, vol.
Predesigned TaqMan primers and probes for IL1B (Hs01555410_m1), TNF (Hs00174128_m1), IL18 (Hs01038788_m1), SERPINE1 (Hs01126606_m1), CD40 (Hs01002913_g1), CCL2 (Hs00234140_m1), and TLR4 (Hs00152939_m1) genes were used (Applied Biosystems).
Researchers studied 177 members of the Berne Amish community in Indiana, and found 43 who had one mutant copy of the gene, SERPINE1.
PLAG1: pleiomorphic adenoma gene 1; BACE1: beta/site APP/ cleaving enzyme 1; CDK6: cyclin/dependent kinase 6; GRN: granulin; DAPK 1: death/associated protein kinase 1; PTEN: phosphatase and tensin homolog; NOTCH 2: Notch 2; NFIA: nuclear factor I/A; SERBP1: SERPINE1 mRNA/binding protein 1; TNC: tenascin C; RASA1: RAS p21 protein activator (GTPase/activating protein) 1; IGFR1: insulin/like growth factor 1 receptor; SP1: Sp1 transcription factor; APBB2: A[beta] precursor protein binding family B member 2; SLC17A6 (DNP1/ [Vglut.sub.2]): solute carrier family 17 member 6 (vesicular glutamate transporter).