SERPINE1

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.
Mentioned in ?
References in periodicals archive ?
Researchers studied 177 members of the Berne Amish community in Indiana, and found 43 who had one mutant copy of the gene, SERPINE1.
The key protein at play in the aging of cells appears to be PAI-1 (plasminogen activator inhibitor,), which is influenced by SERPINE1.
Highly up-regulated genes in colon adenocarcinoma included SERPINE1, previously known as a gene associated with tumor invasion (16,17), and several matrix metalloproteinases, including MMP7 (15).
SERPINE1, ICAM1, F3, MMP3, CCL2, CXCL5, CXCL9, and VCAM1; and CD69, PLAU, PLAT, SELP, SELE, HLA-DRA, IL1 A, PLAUR, SAA1, TIMP2, CCL26, TGFB1, NR4A2, CSF1, and CXCL10: tissue remodeling during inflammation and angiogenesis
157399 B (ovalbumin), member 5 SERPINE1 Serpin peptidase inhibitor, clade 1.
86 Model features Pathways Gene SERPINE1 (PAI-1); MMP9 GO: Process Regulation of angiogenesis; fibrinolysis; blood coagulation; positive regulation of apoptosis KEGG p53 signaling pathway; complement coagulation cascades IPA Coagulation system; acute phase response signaling GO: Function Serine type endopeptidase activity; transmembrane receptor activity; collagen binding GO: Extracellular region; integral to membrane Component ToxCast BSK:BE3C (bronchial epithelial cells): PAI-1 down assays Abbreviations: AUC, area under receiver operating characteristic curve; BA, balanced accuracy; CV, cross validation; MMP9, matrix metalloproteinase 9.