SERPINC1

SERPINC1

A gene on chromosome 1q23-q25.1 that encodes antithrombin III, a member of the serine protease inhibitor (serpin) family that rapidly inhibits thrombin, as well as other activated serine proteases of the coagulation system, and regulates the coagulation cascade.

Molecular pathology
SERPINC1 mutations cause antithrombin-III deficiency.
Mentioned in ?
References in periodicals archive ?
Of these seven gene variants, the strongest evidence for association with DVT was found for three common variants of CYP4V2, a novel cytochrome p450 gene, SERPINC1, and GP6.
The SERPINC1 gene encodes antithrombin, a serine protease inhibitor located on chromosome 1 that plays a central role in natural anticoagulation.