SERPINB5

SERPINB5

A gene on chromosome 18q21.3 that encodes a member of the serine protease inhibitor (serpin) family that acts as a tumour suppressor by blocking the growth, invasion and metastatic properties of mammary tumours. SERPINB5 does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins; it has no serine protease inhibitory activity.
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The selected genes included well-known oncogenes such as FOS and JUN and tumor suppressors such as CDKN1A and SERPINB5 from the top and bottom 60 FA-responsive genes (Tables 3 and 4).
sites (CD6 and SERPINB5) were included in the model from Eipel et al.
* Hypomethylation at specific promoters, resulting in aberrant activation of cancer-inducing genes (i.e., oncogenes) (e.g., SERPINB5) and inducing loss of imprinting at other DNA sites (e.g., IGF2).
(131,132) Other frequently hypomethylated genes, including CLDN4 (chromosome arm 7q, encoding claudin-4), LCN2 (chromosome arm 9q, encoding lipocalin-2), SFN/14-3-3[sigma] (chromosome arm 18q), TFF2 (chromosome arm 21q, encoding trefoil factor 2), MSLN (chromosome arm 16p, encoding mesothelin), and PSCA (chromosome arm 8q, encoding prostate stem cell antigen), are overexpressed in pancreatic cancer cells in comparison with normal pancreatic duct.132 With oligonucleotide microarray technologies, 2 additional genes, S100P (chromosome arm 4p) and SERPINB5 (chromosome arm 18q, encoding maspin), have been identified as being hypomethylated and are overexpressed.6 A selected list of genes that are aberrantly hypomethylated in pancreatic cancer is summarized in Table 3.
have reported that the SERPINB5 gene, coding for maspin, is hypomethylated in placental tissues and hypermethylated in maternal blood cells (11).
The genes that were more highly expressed in carcinomas treated with androgen ablation agents included those encoding AR and steroid biosynthetic enzymes, as well as a suite of genes that have been previously shown to be targets of AR or have been implicated as being regulated by it, including the gene encoding PSA (kallikrein-related peptidase 3), KLK3, and KLK2, as well as DBI, FASN, IL6, SERPINB5, TGFBR3, TMPRSS2, TUBA1, HOXC6, TRG ,and FOLH1.
Subsequently, we discovered the SERPINB5 [5] gene [serpin peptidase inhibitor, clade B (ovalbumin), member 5; also known as maspin] to be hypomethylated in the placenta but completely methylated in maternal blood cells.
The tumor suppressor gene serpin peptidase inhibitor, clade B (ovalbumin), member 5 (SERPINB5; maspin), which is expressed in the placenta (17) and exhibits a tissue-specific methylation pattern (18), is the 1st universal fetal epigenetic marker reported (14).
Lo demonstrated that the tumor suppressor gene RASS-F1A exhibits a pattern of methylation which is reverse to that of SERPINB5, namely hypermethylated in the placenta but hypomethylated in maternal blood cells.
(1) describe a novel approach to the noninvasive prenatal diagnosis of a human chromosomal abnormality by analyzing the allelic ratio of a polymorphism present within the methylated promoter of a DNA sequence on chromosome 18821.3, maspin (SERPINB5).
reported that the maspin (SERPINB5) gene, [6] with its epigenetic differences between the placenta and maternal blood cells, could serve as a universal fetal DNA marker (15).
We recently reported that the maspin (SERPINB5)7 gene promoter was heavily methylated in maternal blood cells and hypomethylated in the placenta (11).