SERPINB3


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SERPINB3

A gene on chromosome 18q21.3 that encodes a member of the serine protease inhibitor (serpin) family thought to act as a protease inhibitor to modulate the host immune response to tumour cells.
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(310) Differentially expressed genes in ALK+ ALCL included genes encoding classical ALCL markers (ALK, CD30, MUC1 or EMA), immunoregulatory cytokines (IL-26, IL-31RA, IL-9, IL-1R2), Th17 cell-associated molecules (IL-17A, IL-17-F, ROR[gamma]), proliferation associated molecules (CCNA1, AGT, PDE4DIP, UPK1B, CDC27), STAT3-regulated targets (SERPINB3, SERPINB4, SOCS1, SOCS3), genes identified in other tumors (RRAD, RAR[alpha], NRCAM, TMEM158, CA12), cytotoxic molecules (PRF1, GZMB), and immunosuppressive response molecules (LILRA3).