SERPINA3

SERPINA3

A gene on chromosome 14q32.1 that encodes a member of the serine protease inhibitor (serpin) family, which is a plasma protease inhibitor.

Molecular pathology
Variations in SERPINA3’s sequence have been implicated in Alzheimer's disease; SERPINA3 deficiency has been linked to liver disease. SERPINA3 mutations have been found in patients with Parkinson disease and COPD.
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Among these 236 DEGs, the top 5 upregulated genes involved NPPA, SFRP4, DSC1, NEB, and FRZB while the top 5 downregulated genes were SERPINE1, SERPINA3, ANKRD2, XRCC4, and S100A8.
The results from PCR demonstrated that the mRNA expression levels of NPPA, SFRP4, DSC1, NEB, and FRZB were significantly higher in the DCM group compared to the healthy group while the mRNA expression levels of SERPINE1, SERPINA3, ANKRD2, XRCC4, and S100A8 in the DCM group were statistically lower than those in the healthy group (Figures 3(a)-3(j)).
Last but not least, many of the hub genes and top 5 downregulated or upregulated genes were also implicated with inflammation and immune response: SERPINA3 (immune response to elevated platelet cytosolic [Ca.sup.2+]), S100A8 (regulating inflammation and oxidative stress, activatingTLR4 signaling), ANKRD2 (a modulator of NF-[kappa]B-mediated inflammatory), FPR1 (G protein-coupled receptor, inflammation), C3 (immune response), CDKN1A (inflammatory response gene), SOCS3 (regulating interleukin), and IL6 (proinflammatory cytokine).
(B) The mRNA expression of SERPINE1, SERPINA3, ANKRD2, ANKRD2, and S100A8 in cardiomyocytes.
(II) In schizophrenia, transcriptome analysis of brain tissue from autopsy of schizophrenic patients showed an increased expression of IFITM2, IFITM3, SERPINA3, and GBP1 was found.
hK2 in blood occurs predominantly in free unbound forms, whereas the majority of PSA is covalently bound in complexes with extracellular antiproteases such as [alpha]-1-antichymotrypsin (encoded by SERPINA3), and only 5%-35% circulates in free unbound forms (10-12).
Alpha-1-antichymotrypsin (ACT), also called SERPINA3 [1], is a member of the serine protease inhibitor (serpin) family of acute phase proteins.