SENP1

SENP1

A gene on chromosome 12q13.1 that encodes sentrin-specific peptidase 1, which has two key roles:
(1) Processing of full-length SUMO1, SUMO2 and SUMO3 to mature forms; and
(2) Deconjugating SUMO1, SUMO2 and SUMO3 from targeted proteins.

It is highly expressed in the testes.
Mentioned in ?
References in periodicals archive ?
Zhang et al., "Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis," The Journal of Biological Chemistry, vol.
In recent studies, it was demonstrated that SENP1 can increase the transcriptional activity of XBP1 through regulating XBP1 SUMOylation.
They identified two genes, ANP32D and SENP1, with significantly increased expression in the CMS individuals when compared to the non-CMS individuals, and hypothesized that down-regulating these genes could be beneficial in coping with hypoxia.
Upon macrophage activation, SUMOylation of IRF-8 is reduced as the deSUMOy-lating enzyme, sentrin-specific peptidase 1 (SENP1), inactivates SUMOylation-related IRF-8 repression.
For instance, it has been reported that androgens enhance the transcription of SENP1, a member of SUMO-specific protease family, showing that the regulation of AR signaling through this protease is based on a positive feedback mechanism [48].