Zhang et al., "Induction of SENP1
in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis," The Journal of Biological Chemistry, vol.
In recent studies, it was demonstrated that SENP1
can increase the transcriptional activity of XBP1 through regulating XBP1 SUMOylation.
They identified two genes, ANP32D and SENP1
, with significantly increased expression in the CMS individuals when compared to the non-CMS individuals, and hypothesized that down-regulating these genes could be beneficial in coping with hypoxia.
Upon macrophage activation, SUMOylation of IRF-8 is reduced as the deSUMOy-lating enzyme, sentrin-specific peptidase 1 (SENP1
), inactivates SUMOylation-related IRF-8 repression.
For instance, it has been reported that androgens enhance the transcription of SENP1
, a member of SUMO-specific protease family, showing that the regulation of AR signaling through this protease is based on a positive feedback mechanism .