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Sec1 Sec2 Sec3 Sec4 Sec5 Sec6 Sec7 0.145 0.323 0.456 0.589 0.655 0.804 0.953 Table 4: The grid information.
The T7 RNA polymerase-controlled expression of M69 aptamer that targets the Sec7 domain of protein cytohesin-1 (cyh1), a protein involved in the control of membrane-associated events and the remodeling of the cytoskeleton, resulted in a cell-spreading deficiency and a dramatic reorganization of F-actin distribution in leukocytes.
STRUCTURE-FUNCTION INVESTIGATION OF THE C-TERMINAL HDS DOMAINS OF THE SEC7 GUANINE NUCLEOTIDE EXCHANGE FACTOR GBF1.
Gene ontology terms revealed for the Q(10)H(2)-sensitive genes an involvement in, e.g., signal transduction processes (centaurin, delta 1; NCOA2; pleckstrin and Sec7 domain containing 3; protein phosphatase 2, regulatory subunit B [B56], [gamma] isoform), transcriptional regulation (NCOA2; POU domain, class 2, transcription factor 1; ETS variant gene 3), and cell proliferation pathways (hypothetical protein FLJ36090, epidermal growth factor receptor pathway substrate 15).
[11] Human genes: GSTP1, glutathione-S-transferase pi; RARB, retinoic acid receptor [beta]; APC, adenomatous polyposis coli; ACTB, [beta]-actin; EDNRB, endothelin receptor type B; RASSF1, Ras association (RalGDS/AF-6) domain family member 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (formerly p16); PSCD2, pleckstrin homology, Sec7 and coiled-coil domains 2 (formerly ARF); MGMT, O-6-methylguanine-DNA methyltransferase.
Specifically, we will focus on the catalytic Sec7 domain of BIG2 which is largely believed to hold the key to selectivity of ARFs.