erythrocyte lactate transporter defect

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erythrocyte lactate transporter defect

An inherited deficiency of lactate transporter (OMIM:245340) that results in an acidic intracellular environment following vigourous exercise, causing muscle degeneration and release of myoglobin and creatine kinase.

Molecular pathology
Caused by defects of SLC16A1, which encodes a proton-coupled transporter that catalyses the movement of monocarboxylates (e.g., lactate and pyruvate) and ketone bodies across the plasma membrane.
References in periodicals archive ?
There is a further suggestion that even if prices rise, at least first-time buyers will not have to find so much cash up front as they won't be paying SDLT.
By using the expressions of deleting regions in (10)~(13), we can construct the decision region of SDLT under the contraints 0 < T [less than or equal to] 4c/[N.sub.0].
The SDLT forms can reportedly be pre-populated with data held within the case management system, eliminating the need to re-key information into the HMRC website.
According to Gartner, this segment will start to diverge, as Quantum's roadmap for SDLT optimizes capacity over performance with a focus on value-added features, such as its DLTice WORM functionality.
The tax planning tip is to check future land arrangements for potential SDLT disasters, plan ahead and thus be prepared.
Pricing starts at USD5,999 for the SDLT 320 and USD8,499 for the LTO-2.
They're likely to be paying more SDLT than Stamp Duty.
SDLT600 will supercede SDLT320, and will deliver what the company claimed is more than doubled throughput and capacity--more than 30Mbytes/sec and 300Gb per cartridge uncompressed--pushing SDLT back into the performance lead over its only major competitor, LTO.
Most studies have concentrated on Alzheimer's disease, vascular dementia and, more recently, senile dementia of the Lewy body type (SDLT).
On 1 April 2018, Land Transaction Tax (LTT) replaced Stamp Duty Land Tax (SDLT).
The acquisition of UK residential property will give rise to tax liabilities and these potentially include stamp duty land tax (SDLT), an annual tax on enveloped dwellings (Ated), income tax and ultimately capital gains tax (CGT) and inheritance tax (IHT).
First-time buyers paying PS300,000 or less for a residential property will now pay no Stamp Duty Land Tax (SDLT).