CXCR4

(redirected from SDF-1 receptor)

CXCR4

A gene on chromosome 2q21 that encodes a seven-transmembrane G protein-coupled receptor belonging to the CXC chemokine receptor family, which binds specifically to stromal cell-derived factor-1, transducing a signal by increasing intracellular calcium ions and enhancing MAPK1/MAPK3 activation. It acts as a receptor for extracellular ubiquitin, is involved in haematopoiesis and in cardiac ventricular septum formation, plays a role in gastrointestinal tract vascularisation by regulating vascular branching and/or remodelling in endothelial cells, may be involved in cerebellar development and, in the CNS, may mediate hippocampal-neuron survival.

Molecular pathology
CXCR4 acts with the CD4 to support HIV entry into cells; it is highly expressed in breast cancer cells. CXCR4 mutations cause WHIM (warts, hypogammaglobulinaemia, infections, and myelokathexis) syndrome.
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References in periodicals archive ?
Accordingly, exposure of ASCs to stressed RPE-CM resulted in the upregulation of the SDF-1 receptor, CXCR4, compared to non-CM (12.6 [+ or -] 4.5-fold) (Figure 3(d)).
Therefore, antibodies against SDF-1 receptor, CXCR4, have the ability to inhibit SDF-1-CXCR4 interaction and prevent tumor growth and angiogenesis.
On the basis of the observation that the chemokine stromal-derived factor 1 (SDF-1) is produced at high concentrations in classic metastatic sites in pancreatic cancer such as the liver, bone, and lung, we found that a subpopulation of [CD133.sup.+] cells that express the SDF-1 receptor CXCR4 (C-X-C chemokine receptor type 4) could be tracked in portal vein blood and that this cell subpopulation drove metastasis exclusively.
To determine the role of SDF-1 in mediating the effects of LMWF, a specific inhibitor of the SDF-1 receptor CXCR4, AMD 3100 (20 microg/kg/day), was used.
Study has indicated that over-expression of SDF-1 can promote the stem and progenitor cell migration to the heart, while administration of free neutralizing SDF-1 antibodies or a SDF-1 receptor blocker diminishes the recruitment of BM-derived cells after MI (Broxmeyer et al.
To investigate whether CB MSC express the two SDF-1 receptors and to determine which receptor mediates SDF-1-directed MSC migration, mRNA was extracted from MSC, and qRT-PCR was performed using primers specific for CXCR4 and CXCR7 Because in rat MSC short-term (3h) VPA treatment more robustly enhances CXCR4 transcript levels compared to long-term (24 h or longer) treatment [14], we exposed human CB-derived MSC to VPA for 3 or 6h.