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tuberculosis expresses an unexpected number of leaderless mRNA transcripts that lack the SD sequence.
However, rarely, some eubacteria have been shown to lack an untranslated leader of sufficient length to contain an SD sequence (Van Etten and Janssen, 1998).
On the other hand, some archae seem to use both SD sequences and leaderless transcripts in their translation initiation process.
The expected SD sequences upstream from start contribute to a distinctive pattern.
However, repeated sampling over the past two years has failed to confirm the existence of the two clades in SD; the four new SD sequences reported here and at least 10 additional partial sequences (Burton, unpubl.