SCN9A

A gene on chromosome 2q24 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN9A protein product plays a major role in nociception signalling.

Molecular pathology
SCN9A mutations are associated with primary erythromelalgia, channelopathy-associated insensitivity to pain and paroxysmal extreme pain disorder.

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References in periodicals archive ?

Another kind of venom--this time from a Chilean tarantula--could hold the key to alleviating pain associated with chronic conditions and an extremely rare illness called inherited erythromelalgia, which is associated with the SCN9A gene.

The Race For The Next Great Painkiller: These new devices and medications could soon shake up the pain management market

A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of DravetSyndrome.

Frequency of acute bacterial meningitis in children with first episode of febrile seizures

SCN9A gene mutation), genetic mutations or changes cannot explain the majority of cases of neuropathic pain.

Treating neuropathic pain: Neuropathic pain is generated after damage or dysfunction in any part of the nervous system; including peripheral nerves, spinal cord, or the brain

An SCN9A Channelopathy Causes Congenital Inability to Experience Pain," Nature 444 (December 14, 2006): 894-98.

Evolution, suffering, and the creative love of God

Ahora se conoce que este padecimiento es causado por mutaciones en el gene SCN9A, que desactiva el canal Nav 1.

Armas contra el dolor cronico: un viejo conocido, los peptidos opioides

A few genetic studies have provided evidence that SCN9A genetic mutations affecting the sodium channel [Na (v) 1.

Congenital indifference to pain: a report of three cases from Pakistan/Konjenital agriya kayitsizlik; Pakistan'dan uc olgu sunumu

Scientists already knew that mutations in another gene, SCN9A, can cause congenital insensitivity to pain (SN: 6/30/12, p.

Gene crucial for feeling pain found: discovery may lead to better drugs for chronic sufferers

For limiting the the SCN9A sodium channel, the novel chemical entity XEN402 is formulated.

Canada : FDA ORPHAN DRUG DESIGNATION being developed to treat pain associated with Erythromelalgia

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.

Immunoreactive evaluation of the extracellular epitope of prostate-specific membrane antigen: in Vitro diagnostic and therapeutic potential

Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders.

The transition from acute to chronic post surgical pain

A Sodium Channel Gene SCN9A Polymorphism that Increases Nociceptor Excitability.

Turning off pain: research has found possible ways to target the problem of neuropathic pain

The researchers found the protein made by the mutated version of the gene known as SCN9A stays open longer than the normal one.