SCN4B

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SCN4B

A gene on chromosome 11q23.3 that encodes a beta subunit of a transmembrane glycoprotein complex, which forms a voltage-gated sodium channel and modulates the kinetics of sodium channel inactivation.

Molecular pathology
SCN4B mutation is linked to long QT syndrome type 10.

References in periodicals archive ?

Ondansetron ([down arrow]) SCN4B in ([up arrow]) SCN4B in (for PFC (Farris et al.

Advances in medications and tailoring treatment for alcohol use disorder

(6) The genes involved in the recent phenotypes LQT9 to LQT13 are; CAV3, SCN4B, AKAP9, SNTA1 and KCNJ5, respectively.

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Long QT and Jervelle Lange-Nielsen syndromes: Genetic defects and channel abnormalities Syndrome Gene Function Autosomal dominant LQT1 KCNQ1 [I.sub.ks] Decreased LQT2 KCNH2 [I.sub.Kr] Decreased LQT3 SCN5A [I.sub.Na] Decreased LQT4 ANK2 [I.sub.Na, K] Decreased LQT5 KCNE1 [I.sub.ks] Decreased LQT6 KCNE2 [I.sub.kr] Decreased LQT7 KCNJ2 [I.sub.k1] Decreased LQT8 CACNA1C [I.sub.Ca,L] Increased LQT9 CAV3 [I.sub.Na] Increased LQT10 SCN4B [I.sub.Na] Increased Autosomal recessive JLN1 KCNQ1 [I.sub.ks] Decreased JLN2 KCNE1 [I.sub.ks] Decreased Cardiac sodium ([I.sub.Na]), Potassium ([I.sub.ks], [I.sub.Kr], [I.sub.k1]) and Calcium currents