SCN2B

SCN2B

A gene on chromosome 11q23 that encodes the beta subunit of the heterotrimeric sodium channel, and plays a key role in its assembly, expression and functional modulation. SCN2B increases the plasma membrane surface area and its infolding into microvilli; it also interacts with TNR and plays a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
References in periodicals archive ?
Ng et al., "Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy," Human Genetics, vol.
En la segunda fase, con las 27 proteinas extraidas (NTRK1, ELAVL1, RAB5A, GTSE1, OCRL, NXF1, GRB2, CLTC, RAB8A, RAB1A, RAB6A, SSX2IP, XPO1, FAM109A, FAM109B, SPINT2, GOLGA5, CEP128, SCLT1, CEP170, HERC2, SCN2B, ENPP6, VSIG4, BTN2A1, CACNG4, RAB14), se construyo una red de interaccion en el Software Cytoscape version 3.3.0 (Shannon, et al., 2003).
Disease or Function p-Value Molecules # Mole Annotation cules Mood disorders 3.73E--04 ADRA2B, ALOX12, AQP4, CA9, 22 CACNB2, CCKBR, CHRNA1, CHR NB4, CHRNG, DDC, ESR1, GRIA3, GRIK2, GRIN1, KCNK2, MTNR 1A, MYOM1, NCAM1, NDUFS7, PDE11A, SCN11A, SCN2B Depressive disorder 7.90E--04 ADRA2B, AQP4, CACNB2, 14 CCKBR, CHRNA1, CHRNB4, CHRNG, ESR1, GRIA3, GRIN1, KCNK2, MYOM1, NCAM1, PDE11A Table 3 Effect of Rhodiola on genes involved in depression ([section]).