SCN1B

SCN1B

A gene on chromosome 19q13.1 that encodes a beta subunit of a transmembrane glycoprotein complex, which forms a voltage-gated sodium channel. The beta-1 subunit modulates the kinetics of channel inactivation.

Molecular pathology
SCN1B mutations are linked to generalised epilepsy with febrile seizures, Brugada syndrome 5 and defects in cardiac conduction.
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References in periodicals archive ?
SCN1A genindeki de novo islev kaybi mutasyonlari cogu olgudan sorumlu olmakla beraber SCN1B, SCN2A, GABRG2, GABRA1, STXBP1, PCDH19 mutasyonlari pozitif olan ya da klinik olarak Dravet Sendromu tanisi alip mutasyon saptanamayan olgular da vardir (7, 8).
Generalized epilepsy with febrile seizures plus(GEFS+): clinical spectrum in seven Italian families unrelated to SCN1A, SCN1B and GABRG2 gene mutations.
Six other genes (CACNA1C, CACNB2, SCN1B, KCNQ3, SCN3B, and HCN4) have been associated with BrS, but the prevalence of variants in these genes is yet unknown (6).
Ng et al., "Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy," Human Genetics, vol.
These mutations include but are not limited to the SCN5A, GPD1-L, CACNA1C, CACNB2, SCN1B, KCNE3, SCN3B, and HCN4genes (5).