Severe Leukopenia and Dysregulated Erythropoiesis in SCID Mice
Persistently Infected with the Parvovirus Minute Virus of Mice'.
The partnership's preliminary results using FCX-007 cells in a human skin graft model showed no findings of toxicology in RDEB human skin xenograft severe combined immunodeficiency (SCID) mice, additional positive proof-of-concept data from in vivo pre-clinical studies showed the presence of COL7 in the dermal-epidermal junction of the RDEB cultured grafts in RDEB human skin xenograft SCID mice
and found no systemic distribution of the vector in normal human skin xenograft SCID mice
4 years) was grafted to beige SCID mice
, and epidermal thickness, proliferation (Ki-67 expression), apoptosis (TUNEL [Tdt-mediated dUTP nick end labeling] reaction below granular layer), and expression of Fas and FasL were determined by histology and immunochemical staining.
Breeding diabetes scid mice
with streamline cabinet.
Called severe combined immunodeficient mice, or SCID mice
, they have the equivalent of what is known as "bubble boy" disease.
These included muscle weight increase in SCID mice
efficacy studies, muscle circumference changes in a 39-week toxicology study in monkeys, and total myostatin levels observed in multiple-ascending dose (MAD) studies in Phase I/II trials.
The paper highlights that human VSEL stem cells form human bone when implanted in the bone tissue of SCID mice
Aaron Havens of the University of Michigan, involved isolating G-CSF mobilized VSEL stem cells from the blood of healthy donors and transplanting them into burr holes made in the cranial bones of SCID mice
Methods: Human melanoma MV3 cells were subcutaneously xenografted into scid mice
, and pML-I or ML-I equivalent doses of Iscador M[R], respectively, were administered i.
Chinese red yeast rice inhibition of prostate tumor growth in SCID mice
3-16 deletion, are tumorigenic in SCID mice
(Russo et al.
We have previously shown that inhibition of leptin signaling with pegylated leptin peptide receptor antagonist 2 (PEG-LPrA2) negatively impacted on the growth of mouse syngeneic and human breast cancer xenografts hosted by SCID mice
, PEG-LPrA2 effects paralleled a significant reduction of VEGF/VEGFR2 levels.