possess an autosomal recessive mutation developed in C.B-17 mice, which are a congenic and inbred strain of BALB mice.
Follicular development from ovarian xenografts in SCID mice
Tumorigenicity Analysis in SCID Mice
. Tumor-positive cell suspension was made with the cell concentration of 1 x [10.sup.6]/mL.
The development of nonobese diabetic- (NOD-) scid mice
further improved the engraftment in comparison to previous immunodeficient host types .
'Severe Leukopenia and Dysregulated Erythropoiesis in SCID Mice
Persistently Infected with the Parvovirus Minute Virus of Mice'.
After implanting human islets into scid mice
, lesogaberan significantly increased [beta]-cell replication in the islet grafts.
have some limitations such as nonavailability in most laboratories and cumbersome to work with because of their severely impaired immune systems and the requirement for them to be kept in sterile conditions to prevent opportunistic infections .
The partnership's preliminary results using FCX-007 cells in a human skin graft model showed no findings of toxicology in RDEB human skin xenograft severe combined immunodeficiency (SCID) mice, additional positive proof-of-concept data from in vivo pre-clinical studies showed the presence of COL7 in the dermal-epidermal junction of the RDEB cultured grafts in RDEB human skin xenograft SCID mice
and found no systemic distribution of the vector in normal human skin xenograft SCID mice
On the other hand, our observations of FT induction in SCID mice
, but not MyD88 knockout mice, the involvement of a proteinaceous substance present in the small intestinal homogenate, and the selective expression of FGA1 in villus epithelial cells suggest that proteinaceous substances produced by non-T and non-B cells may mediate FT induction in villus epithelial cells.
Skin from aged participants (n = 14; mean 70.7 years), and young participants (n = 14; mean 23.4 years) was grafted to beige SCID mice
, and epidermal thickness, proliferation (Ki-67 expression), apoptosis (TUNEL [Tdt-mediated dUTP nick end labeling] reaction below granular layer), and expression of Fas and FasL were determined by histology and immunochemical staining.
Previous studies have showed that laminar flow cabinet in common laboratory animal facility can provide a local SPF condition and can be successfully used to breed nude mice (Li et al., 2003) and diabetes Scid mice
(Li et al., 2005) which are both immune-deficient mice.