NF2

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NF2

NF2

A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).

Neurofibromatosis type 2 (NF2)

A hereditary condition associated with an increased risk of bilateral acoustic neuromas, other nerve cell tumors and cataracts.
Mentioned in: Acoustic Neuroma
References in periodicals archive ?
Currently, the SCH is in the process of administering the flu vaccine to all healthcare professionals.
The team at SCH Trade would like to invite customers online to browse the latest range of cheap refurbished and brand new laptops for 2012 online at http://www.
As per the new law, all drug firms and importers, apart from the existing ones, may now do business in Qatar provided they comply with the requirements and standards set out by the SCH.
Treating patients with SCH improves cardiovascular risk factors.
5 billion euros and trading through ETC, Bestware and Interchange, SCH is a market leader in valued added distribution in the UK, France and The Netherlands.
Matt Cooney, chief executive of SCH, said: "By making a commitment to continuously improving the way that we work with our partners in the construction industry, we are not only making sure that we foster good working relationships with them, but that our building projects provide value for money and meets the needs of our customers.
He will continue to work with SCH as a senior adviser to chairman Emilio Botin.
SCH hope to complete their takeover of Abbey before the end of the year, although they still face the possibility of a rival bid from HBOS.
But it was reported yesterday that SCH will walk away if the involvement of HBOS drags Abbey into a protracted investigation by competition authorities.
CINCINNATI, March 3 /PRNewswire/ -- SCH Technologies today
Earlier this summer, SCH announced the completion of a core drilling program and released a preliminary JORC-compliant resource statement of 352 metric tons (Mt) in the Penrhyn deposit with a further exploration target of 300 to 330 Mt.