NF2

(redirected from SCH)
Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

NF2

NF2

A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).

Neurofibromatosis type 2 (NF2)

A hereditary condition associated with an increased risk of bilateral acoustic neuromas, other nerve cell tumors and cataracts.
Mentioned in: Acoustic Neuroma
References in periodicals archive ?
The SCH will not approve the premises if it is attached to commercial or residential premises.
Furthermore, the SCH is building a 5-star behavioural disorder centre, a national reference laboratory, and two food testing branches.
Inclusion Criteria: Consecutive patients with SCH attending our outpatient clinic were enrolled between January 2012 and June 2012.
He added that the move was also a reflection of the vision of the Heir Apparent His Highness Sheikh Tamim bin Hamad al Thani, Chairman of SCH, and Her Highness Sheikha Mozah bint Nasser al Missned, the Vice-Chairman of SCH, of a healthy environment in the drug market that will allow for the provision of affordable and quality drugs to all sections of society in the country.
SCH or GOM at concentrations up to 100 [micro]M did not alter cellular GSH level (p>0.
A 2006 meta-analysis of 14 observational studies came to a similar conclusion: SCH significantly increased the risk of coronary heart disease, with an odds ratio of 1.
SCH hopes to complete the acquisition by the end of the year, but must first win the approval of shareholders.
SCH is dependent on these funds for profitability and management expects these payments to be largely flat in 2013.
The SCH Secretary-General Ebrahim Al-Nawakhdha said that HRH the Prime Minister's directives would improve health services and ensure better health care for the citizens.
Although treating patients with SCH may improve some lipid profiles, there is scanty evidence that it benefits quality of life, cardiovascular health, or mortality rates.
Birmingham-based technology giant SCH today named James Rigby as the managing director of its UK operations.
Specifically, SCH recorded its highest profit ever in fiscal 2011 (June 30; audited) with $13.