Kowalska, "The assessment of the prognostic value of tumor markers and cytokines as SCCAg
, CYFRA 21.1, IL-6, VEGF and sTNF receptors in patients with squamous cell cervical cancer, particularly with early stage of the disease," Tumour Biology, vol.
Detection of serum tumor markers: Blood samples of the two groups were retained to detect tumor markers using chemiluminescence assay, including cytokeratin 19 fragment (CYFR21-1), carbohydrate antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and squamous cell carcinoma-associated antigen (SCCAg).
Levels of serum tumor markers before and after chemotherapy: The levels of serum tumor markers (CYFR21-1, CA19-9, CEA, SCCAg) significantly decreased after PC and PF treatments compared with those before (P<0.05) (Table-IV).
CYFR21-1, CA19-9 and SCCAg are significantly correlated with tumor stage and histological type.14-16
Currently the screening and early diagnosis of lung cancer relies mainly on chest x-ray, low-dose computed tomography, bronchoscopy, sputum cytology, and tumor markers including carcinoembryonic antigen (CEA), cytokeratin-19 fragments (Cyfra21-1), carbohydrate antigen 19-9 (CA19-9), squamous cell carcinoma antigen (SCCAg
), and neuron-specific enolase (NSE).
In the clinical diagnosis of NSCLC, carcinoembryonic antigen (CEA), cytokeratin 19 fragments antigen (CYFRA21-1), and squamous cell carcinoma antigen (SCCAg) have been used as reference TM for NSCLC.
The level of SCCAg may be correlated with the highly differentiated squamous cell carcinoma of the lung.
However, some serum tumor markers, such as carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCCAg
), soluble cytokeratin 19 fragments (CYFRA 21-1), and tissue polypeptide antigen (TPA), continue to be utilized in clinic despite their poor sensitivity and specificity.