SERPINB4

(redirected from SCCA2)
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SERPINB4

A gene on chromosome 18q21.3 that encodes a member of the serine protease inhibitor (serpin) family thought to act as a protease inhibitor to modulate the host immune response to tumour cells.
References in periodicals archive ?
11-13 SCCA1 and SCCA2 are the genes coding SCCA that is intrinsically a serine protease inhibitor, and SCCA2 is located next to the gene breakpoint of 18-trisomysyndrome patients.
Table-III: SCCA2 expression changes before and after chemotherapy.
15,16 Given that most SCCA-related studies only focused on overall SCCA genes, detecting SCCA2 may work in evaluating therapeutic effects.
SCCA2 was used instead of SCCA in practice because SCCA1 and SCCA2 function differently.
However, studies on SCCA1 and SCCA2 remain limited, especially for the debate on the correlation between SCCA and pathological parameters of cervical squamous cell carcinoma.
As a result, clarifying the effects of SCCA1 and SCCA2 on clinical detection and prognosis is particularly necessary, which requires top-notch detection techniques and large-scale studies.
In summary, we found that only SCCA2 was expressed significantly differently in cervical squamous cell carcinoma patients and normal controls.