Relative Expression Rates of SCCA1 and SCCA2 before Treatment: The two groups had similar relative SCCA1 expression rates (P Greater than 0.05), whereas the relative SCCA2 expression rate of the study group (4.396+-2.002) was significantly (P=0.0000982 Less than 0.05) lower than that of the control group (9.028+-3.182) (Table-I and Fig.2).
In this study, relative SCCA1 expression rates of the two groups were similar (P Greater than 0.05), suggesting that SCCA1 expression did not exert specific effects on the onset and diagnosis of cervical cancer.
Besides being the marker of cervical squamous cell carcinoma, SCCA is also the marker of lung cancer.11-13 SCCA1 and SCCA2 are the genes coding SCCA that is intrinsically a serine protease inhibitor, and SCCA2 is located next to the gene breakpoint of 18-trisomysyndrome patients.14 The two genes, which share a homology of 92%, code neutral
SCCA2 was used instead of SCCA in practice because SCCA1 and SCCA2 function differently.
However, studies on SCCA1 and SCCA2 remain limited, especially for the debate on the correlation between SCCA and pathological parameters of cervical squamous cell carcinoma.