SC disease

SC disease

Sickle-hemoglobin C disease A hemoglobinopathy affecting circa 1:800 US blacks, characterized by ↑ infections–eg, bacterial meningitis, Salmonella osteomyelitis due to a defect in the alternate–properdin complement pathway; other effects of SC disease include osteoporosis–resulting in formation of 'fishmouth vertebrae', nephropathy with ↓ renal concentration, acidification, ↑ glomerular filtration rate, retinopathy–in ± 75% of SCD vs 15% of Pts with sickle cell anemia Fundoscopy 'Black sunburst' pattern, due to ↑ glycolysis in end-arterioles; 'seafoam' pattern of proliferative retinopathy Lab ↑ 2,3 DPG, ↑ factor VIII; ↓ osmotic fragility; reticulocytes comprise 5-25% of peripheral RBCs, which have a 'holly-leaf' or navicular shape. See Sickle cell anemia.
References in periodicals archive ?
Hemoglobin SC disease, is a type of sickle cell disease, which means it affects the shape of the red blood cells.
This is a unique case of massive ovarian edema caused by a vasoocclusive crisis in a girl with hemoglobin SC disease.
Hemoglobin SC disease and hemoglobin S[[beta].sup.+] thalassemia are other common forms of SCD.
Functional asplenia in hemoglobin SC disease. Blood 1995 Apr; 85(8):2238-2244.
Sickle cell anemia (HbSS/HbS-Beta thalassemia zero) accounts for 70% of cases of sickle cell disease in populations of African ethnicity, with most of the remainder having hemoglobin SC disease (HBSC disease) due to the coinheritance of the [[beta].sup.s] and [[beta].sup.c] alleles [2,3].
Mobile Right Atrial Thrombi in a Patient with the Hemoglobin SC Disease. Case Rep Med.
There have been case reports of luteal cyst rupture with massive hemoperitoneum during dialysis, thrombolytic therapy, patient with Hb SC disease, liver disease and patient on anticoagulation therapy.
The above cases represent four different scenarios of SC disease in children with malignancies.
Some people with this genotype develop Hb SC disease, a variant of sickle cell disease.
We encountered a 62-year-old man with hemoglobin (Hb) SC disease. Diabetes mellitus had been previously diagnosed in this patient on the basis of 2 increased fasting glucose values.
Hydroxyurea therapy for pediatric patients with hemoglobin SC Disease. Journal of Pediatric Hematology/Oncology, 23(5), 306-308.
'Haemoglobin SC disease' and 'sickle beta thalassaemia' are similar conditions.