MAPK13

(redirected from SAPK4)

MAPK13

A gene on chromosome 6p21.31 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK13 is phosphorylated and activated by MAP kinases—especially MKK3 and MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress, and in turn phosphorylate downstream targets.

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References in periodicals archive ?

The p38 MAPK family members (p38, MAPK11, SAPK3, and SAPK4) are activated by inflammatory cytokines, UV radiation, and external stress such as heat shock and high osmotic stress.

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-[kappa]B

In rice, SAPK4 overexpression under salt stress significantly improved the seed germination, plant growth, and development.

Plant salt stress: adaptive responses, tolerance mechanism and bioengineering for salt tolerance

Sengupta, "Spermidine-mediated in vitro phosphorylation of transcriptional regulator OSBZ8 by SNF1-type serine/threonine protein kinase SAPK4 homolog in indica rice," Acta Physiologiae Plantarum, vol.

Mechanism of salinity tolerance in plants: physiological, biochemical, and molecular characterization

Cohen, "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases," The EMBO Journal, vol.

P38[delta] MAPK: emerging roles of a neglected isoform

To date, 4 isoforms of the p38 family have been identified: p38[alpha], p38[beta], p38[gamma] (extracellular signal-regulated kinases 6, SAPK3), and p38[delta] (SAPK4).