MAPK11

(redirected from SAPK2)
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MAPK11

A gene on chromosome 22q13.33 that encodes a member of the MAP kinase family, which integrate multiple biochemical signals and are involved in cell proliferation, differentiation, transcription, regulation and development. MAPK11 is preferentially activated by MAPK kinase—especially MKK6; it is closely related to p38 MAP kinase and both are activated by pro-inflammatory cytokines and environmental stress.
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References in periodicals archive ?
Pharmacological inhibitors were used such as Wortmannin, Bay 11-7082, Genistein, GF109203X, PD98059, SB203580, SP600125, and U-73122 (Cell Signaling Technology, Danvers, MA) for the inhibition of phosphoinositide 3-kinase (PI3K), IkB-[alpha] phosphorylation, protein tyrosine kinase (PTK), protein kinase C (PKC), MEK1, sApK2 (p38), jun N-terminal kinase (JNK), and phospholipase C (PLC), respectively.