SAPHO syndrome


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SAPHO syndrome

Synovitis Acne Palmoplantar Pustulosis Hyperostosis Osteitis. A rare association of severe acne and arthralgia/arthritis, which is more common in men.
 
Clinical findings
The acne affects the face, upper back and trunk, and is accompanied by fever and weight loss. The pain usually affects the hips, knees, shoulders, and occasionally other sites. The arthritis usually affects the lower limbs; it may be acute and polyarticular.
 
Lab
Increased erythrocyte sedimentation rate (ESR), increased leukocytes, decreased serum complement, negative ANA, negative rheumatoid factors, presence of circulating immune complexes.
 
Management
NSAIDs for pain, arthritis; corticosteroids for severe pain and recalcitrant acne.

SAPHO syndrome

A syndrome characterized by synovitis, acne, pustulosis, hyperostosis, osteitis
References in periodicals archive ?
They also recognized a range of associated disorders, including SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis), PAPA syndrome (pyogenic arthritis, pyoderma gangrenosum, and acne), and PASH (pyoderma gangrenosum, acne, and hidradenitis suppurativa).
To the Editor: SAPHO syndrome is a heterogeneous disorder characterized by synovitis, acne, pustulosis, hyperostosis, and osteitis.
Diagnosis of SAPHO syndrome depends on the presence of at least one of three diagnostic criteria including osteoarticular manifestations of severe acne or palmoplantar pustulosis; hyperostosis of the anterior chest wall, limb, or spine; or chronic recurrent multifocal osteomyelitis (CRMO).
Spondylodiscitis in SAPHO syndrome is sometimes difficult to distinguish from infectious spondylodiscitis.
5) Biopsy of the disk space in patients with SAPHO syndrome reveals chronic sterile nonspecific inflammation.
4) SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is an inflammatory bone disorder that commonly presents with skin manifestations.
Insidious onset of intermittent pain and swelling in the bone and joints (bilateral and symmetrical) are characteristic features of the SAPHO syndrome.
18) As well, bisphosphonate therapy may be beneficial in conditions that mimic osteonecrosis such as SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) of the mandible, in which the histologic appearance may resemble that of osteonecrosis.
Reported risk factors for PSO include intravenous drug abuse with or without antecedent history of blunt trauma, acquired immunodeficiency syndrome, hemoglobinopathies and SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteomyelitis) [4,11].
He was forced to leave the navy at the age of 30 and now, at 63, takes painkillers every day to deal with the debilitating effects of SAPHO Syndrome, which effects the muscular and skeletal systems.
The ex-Royal Engineer, of Johnstone, Renfrewshire, has Sapho Syndrome, an immune system disorder.
Acne fulminans is a component of SAPHO syndrome (acronym for Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis).