SAMSN1

SAMSN1

A gene on chromosome 21q11 that encodes a protein which downregulates B-cell activation and cell proliferation. It upregulates RAC1-dependent membrane ruffle formation and reorganisation of the actin cytoskeleton and HDAC1 activity. SAMSN1 regulates cell spreading, cell polarisation and LYN activity by modulating its tyrosine phosphorylation; it is upregulated in B cells by IL4, IL13 and by CD40, and it interacts with CTTN, FASLG, HDAC1, SAP30, SFN, YWHAB, YWHAE, YWHAG, YWHAH and YWHAZ.
References in periodicals archive ?
Some genes involved in B cell activity (CD83 molecule, CD72 molecule, Fc receptor-like 2, FCRL2, and SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1)) are modulated in patients' samples, indicating a concomitant activation of this lymphocyte cell subset in BD.
Among DEGs regulating B cell responses, we observed overexpression of SAMSN1, a transcript induced upon B cell activation [59], and EGR1, involved in the differentiation program of B cells into plasma cells, whereas the inhibitory receptor CD72 that downmodulates B cell receptor (BCR) signaling was downregulated.