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substance

 [sub´stans]
1. physical material that has form and weight; called also matter.
2. the material constituting an organ or body.
substance Abuse and Mental Health Services Administration (SAMHSA) an agency of the United States Department of Health and Human Services, created in 1992 to oversee the quality and availability of programs for prevention, treatment, and rehabilitation of substance abuse and related mental health problems.
black substance substantia nigra.
controlled substance a psychoactive substance that is regulated under the controlled substances act. See table at drug dependence.
depressor substance
gray substance gray matter.
ground substance the gel-like material in which connective tissue cells and fibers are embedded.
substance-induced disorders a subgroup of the substance-related disorders comprising a variety of behavioral or psychological anomalies resulting from ingestion of or exposure to a drug of abuse, medication, or toxin. Included are substance intoxication, substance withdrawal, and other mental disorders such as dementia, mood disorder, and psychotic disorder when they are specifically caused by a substance. See also substance use disorders.
medullary substance
1. the white matter of the central nervous system, consisting of axons and their myelin sheaths.
2. the soft, marrow-like substance of the interior of such structures as bone, kidney, and adrenal gland.
müllerian inhibiting substance a glycoprotein produced by the Sertoli cells of the fetal testis that acts ipsilaterally in the male to suppress the müllerian ducts, consequently preventing development of the uterus and fallopian tubes, thus helping to control formation of the male phenotype.
substance P a peptide composed of 11 amino acids, present in nerve cells scattered throughout the body and in special endocrine cells in the gut; it increases the contractions of gastrointestinal smooth muscle and causes vasodilatation; it is one of the most potent vasoactive substances known, and it seems to be a sensory neurotransmitter involving pain, touch, and temperature.
perforated substance
1. anterior perforated substance, an area anterolateral to each optic tract, pierced by branches of the anterior and middle cerebral arteries.
2. posterior perforated substance, an area between the cerebral peduncles, pierced by branches of the posterior cerebral arteries.
pressor substance vasopressor (def. 2).
psychoactive substance (psychotropic substance) any chemical compound that affects the mind or mental processes, particularly a drug used therapeutically in psychiatry, or any of various other types of mind-altering substances such as drugs of abuse and some toxins. See also table at drug dependence. Called also psychoactive agent or drug and psychotropic agent or drug.



There are several different classes of psychoactive substances: antidepressants are used for the relief of symptoms of major depression. lithium is the most common agent used to treat manic episodes of bipolar disorder. antipsychotic agents (or major tranquilizers) are used for management of the manifestations of psychotic disorders such as schizophrenia. antianxiety agents (called also minor tranquilizers), such as diazepam (Valium), are used for relief of anxiety disorders. While none of these drugs can effect a cure, they can reduce the severity of symptoms and permit the patient to resume more normal activity.

Also included in the category of psychotropic drugs are many other substances that affect the mind but are not used to treat mental disorders, including stimulants such as caffeine, amphetamines, and cocaine; opiates; and hallucinogens.
substance-related disorders any of the mental disorders associated with excessive use of or exposure to psychoactive substances, including drugs of abuse, medications, and toxins. The group is divided into substance use disorders and substance-induced disorders, each of which is specified on the basis of etiology, such as alcohol use disorders. See also drug abuse and drug dependence.
slow-reacting substance of anaphylaxis SRS-A, an inflammatory agent released by mast cells in the anaphylactic reaction. It induces slow, prolonged contraction of certain smooth muscles and is an important mediator of allergic bronchial asthma.
threshold s's those substances in the blood, such as glucose, that are excreted when they reach their renal threshold.
transmitter substance neurotransmitter.
substance use disorders a subgroup of the substance-related disorders, in which psychoactive substance use or abuse repeatedly results in significantly adverse consequences. The group comprises substance abuse (see drug abuse) and substance dependence (see drug dependence); specific disorders or groups of disorders are named on the basis of etiology, e.g., alcohol use disorders, alcohol abuse, and alcohol dependence.
white substance white matter.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
References in periodicals archive ?
Despite the reports of SAMHSA's imminent demise, nearly a year elapsed between Dr.
The final rule states that health care operations under the SAMHSA regulations do not include activities such as care coordination, case management, patient diagnosis, patient treatment or referral for patient treatment.
But SAMHSA is not letting lawful information holders share a patient's information with care coordinators or case managers without getting separate, express consent from the patient.
SAMHSA also permits data linkages to enable researchers to link to data sets from data repositories holding Part 2 data if certain regulatory requirements are met.
SAMHSA is working quickly with training providers to help them adapt curricula and obtain continuing education credits for this important training.
* Wide variability exists in quality and comprehensiveness of treatment for opioid addiction; clinical practice guidelines should supplement but not replace regulations, and should provide a vehicle by which patient care may be improved (SAMHSA 2000, p.
While the amount of heroin consumers in recent research is consistent with levels measured since 2009, it is significantly higher than in 2002, according to the SAMHSA.
SAMHSA also notes more than eight out of 10 people who needed such treatment did not perceive a need for it.
Hyde of the Substance Abuse and Mental Health Services Administration (SAMHSA) said during a press conference held to review key results of the 2013 National Survey on Drug Use and Health (NSDUH).
In 2012, 7% of survey respondents said they were current users of marijuana, meaning they had used it at least once within 30 days prior to taking the survey, SAMHSA Administrator Pamela Hyde said at the press briefing.
"These findings show that while we have made progress in preventing some aspects of substance abuse, we must redouble our efforts to reduce and eliminate all forms of it throughout our nation," said SAMHSA Administrator Pamela Hyde, JD.
Westley Clark, M.D., director of the Substance Abuse and Mental Health Services Administration's (SAMHSA) Center for Substance Abuse Treatment, spoke to attendees of the Health Care Special Session and Luncheon.