identified several neurodevelopmental-related transcription factors (POU3F2, SOX2, SALL2
, and OLIG2) and found that overexpression of either transcription factor induces reprogramming of differentiated GBM cells into stem cell-like GBM cells.
Importantly, ARNT2, MYB, XBP1, and SALL2 are the candidate drivers for attenuating histological grade promotion (Figure S6.7).
The most interesting finding is the inferred target genes of both MYB and ARNT2 including POU2F1, SALL2, and XBP1.
Additionally, MYB may promote good prognosis via up-regulating NTN4 and SALL2. NTN4 is a good prognostic factor .
The functional annotated 41-gene prognostic signature indicates the major contributors associated with the prognostic features of MYB including up-regulating the transcriptional activities of three transcription factors--POU2F1, SALL2, and XBP1 which are also favorable prognostic indicators in 90A cohort and 181A cohort.