PLK4

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PLK4

A gene on chromosome 4q27-q28 that encodes a member of the CDC5/Polo subfamily of serine/threonine protein kinases. PLK4 plays a central role in centriole duplication and is also involved in trophoblast differentiation by phosphorylating HAND1, which disrupts the HAND1/MDFIC interaction, leading to HAND1 activation. It also phosphorylates CDC25C and CHEK2. PLK4 is downregulated by p53/TP53.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Viscous production comes from ConocoPhillips-operated Tabasco and West Sak fields, and BP's Orion, Polaris and a portion of the Schrader Bluff formation from the Milne Point field, according to Arctic Energy, a North Slope overview booklet published by producers ConocoPhillips and BP Exploration in April 2006.
It makes no difference if you spend 14 hours at the work place, if half the time you are dozing off or don't know what to do," said SAK vice chair Matti Huutola, according to the Finnish news agency STT.
Tom Talucci, brother of The Sak co-founder Mark Talucci, is the creative director for Home, which now includes pillows, scatter rugs, throws, furniture, table runners, placemats and napkins.
SAK is developing its SueEo Compound on 11 feddan in the R7 at the NAC with a built-up area of 14.8%.
SAK Holding Group chairman Sheikh Thani bin Abdullah al-Thani lauded the completion of the iconic hotel project and underscored the significance of the private sector's role in the hospitality sector.
Sak Abrasives Inc said there is considerable value in a Made in USA brand and the company's vision is to allow customers across the globe the choice of products manufactured in different geographies with varying price/quality.
Now 64, Sak says the dates grown there are better than the ones grown in arid countries overseas - the more common sources - thanks to Thailand's rainfall.
But at the same time, they stood for the fact that Islam, the national traditions, and customs should be wrapped in cotton-wool, the religion of the ancestors and as the source of the spiritual values (Sak, 2014).
A notorious drug peddler identified "Sak," was killed after he engaged lawmen in a shootout.
District police chief Superintendent Som Sak Din Keliaw said, "As he was trying to overtake the trailer, the victim lost control of his vehicle and he crashed onto the trailer in front.
"Because there is a disproportionate amount of weight in the top third of the bottle where the handle is, the bottle has very, very good top-load strength," says Barry Sak, vice president of business development at Pretium Packaging.
The real estate report, issued by the Market Watch Bureau of the diversified Doha-based SAK Holdings Group, said that the decision to cut down production will have positive effects on the real estate sector and will be an incentive for launching new projects.