RPS6KA4

(redirected from S6K-alpha-4)

RPS6KA4

A gene on chromosome 11q11-q13 that encodes a p90 ribosomal S6  serine/threonine-protein kinase required for the mitogen or stress-induced phosphorylation of transcription factors CREB1 and ATF1, as well as for regulating transcription factor RELA. RPS6KA4 contributes to gene activation by histone phosphorylation and helps regulate inflammatory genes; it is thought to induce transcription of the MAP kinase phosphatase DUSP1 and IL10 (an anti-inflammatory cytokine) via CREB1 and ATF1 transcription factors.

Molecular pathology
Aberrant activation of p90 RSKs has been linked to breast and prostate cancers.
References in classic literature ?
A city house in a fashionable street, not so showy as our big houses, but twice as comfortable and full of solid luxury, such as English people believe in.
To save you the trouble of wading through a lot of scientific detail, which I know you don't care about, I'll tell you that the story is about a queer idol of solid gold, weighing many pounds, and, in consequence, of great value.
They made a tunnel through the snow to the hen-house, with walls so solid that grandmother and I could walk back and forth in it.
There were a number of bath-houses along the beach, of rough but solid construction, built with small, protecting galleries facing the water.
these Frenchers will pull it to pieces faster than it was put together, solid and thick though it be
This impalpable claim, therefore, resulted in nothing more solid than to cherish, from generation to generation, an absurd delusion of family importance, which all along characterized the Pyncheons.
Dimmesdale had lived; and who might well, therefore, be more profoundly versed in such solid and valuable attainments than their youthful brother.
The right one suddenly presented itself to me as the lower one-- though high above the gardens--in the solid corner of the house that I have spoken of as the old tower.
His whole high, broad form, seemed made of solid bronze, and shaped in an unalterable mould, like Cellini's cast Perseus.
Moreover, while in most other animals that I can now think of, the eyes are so planted as imperceptibly to blend their visual power, so as to produce one picture and not two to the brain; the peculiar position of the whale's eyes, effectually divided as they are by many cubic feet of solid head, which towers between them like a great mountain separating two lakes in valleys; this, of course, must wholly separate the impressions which each independent organ imparts.
said the man, drawing out a paper; "this yer's the bill of sale, and there's your master's name to it; and I paid down good solid cash for it, too, I can tell you,--so, now
I was put into a jail once on this account, for one night; and, as I stood considering the walls of solid stone, two or three feet thick, the door of wood and iron, a foot thick, and the iron grating which strained the light, I could not help being struck with the foolishness of that institution which treated my as if I were mere flesh and blood and bones, to be locked up.