S1PR2

S1PR2

A gene on chromosome 19p13.2 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor, which participates in sphingosine 1-phosphate-induced cell proliferation, survival and transcription activation.
References in periodicals archive ?
In the small intestine, all genes (BRMS1, DSP, E2F6, NUMA1, and PPAP2A) except S1PR2 were directly connected with ubiquitin C to form a network concerned with cancer, cell to cell signaling and interaction and cellular growth and proliferation.
Scientists at Washington University School of Medicine in the US found higher levels of protein S1PR2 in tests on the brains of femalemice and dead women with MS than in male equivalents, BBC Newsreports Four times more women than men are currently diagnosed with MS.
Scientists studied the blood vessels and brains of healthy mice, mice with MS, and mice without the gene for S1PR2, a blood vessel receptor protein, to see how it affected MS severity.
They found high levels of S1PR2 in the areas of the brain typically damaged by MS in both mice and people.
The activity of the gene coding for S1PR2 was positively correlated with the severity of the disease in mice, the study said.
Louis, females susceptible to MS produce higher levels of a blood vessel receptor protein, S1PR2, than males and that the protein is present at even higher levels in the brain areas that MS typically damages.
Researchers found MS - which affects balance and vision and leaves sufferers exhausted - is linked to the gene S1PR2.
Scientists are now trying to develop a drug to block S1PR2 as well as a "tracer" to monitor levels of the gene so that people can track their condition.
Prof Klein of Washington University in St Louis, Missouri, said the S1PR2 gene could be allowing inflammatory cells that cause MS to get into the nervous system.
46 7SK RNA [Source:RFAM;Acc:RF00100] ENSSSCG00000012939 BRMS1 breast cancer metastasis suppressor 1 [Source:HGNC Symbol;Acc:17262] ENSSSCG00000013658 S1PR2 sphingosine-1-phosphate receptor 2 [Source:HGNC Symbol;Acc:3169] ENSSSCG00000026161 E2F6 E2F transcription factor 6 [Source:HGNC Symbol;Acc:3120] ENSSSCG00000001025 DSP desmoplakin [Source:HGNC Symbol;Acc:3052] ENSSSCG00000014802 NUMA1 nuclear mitotic apparatus protein 1 [Source:HGNC Symbol;Acc:8059] ENSSSCG00000016912 PPAP2A phosphatidic acid phosphatase type 2A [Source:HGNC Symbol;Acc:9228] ENSSSCG00000030936 CH242-154K8.