S1PR4

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S1PR4

A gene on chromosome 19p13.3 that encodes an EDG (endothelial differentiation, G protein-coupled) family receptor for sphingosine 1-phosphate, a bioactive lysophospholipid that regulates cell proliferation, apoptosis, motility and neurite retraction. It acts intracellularly as a second messenger and extracellularly as a receptor ligand, and it elicits diverse physiologic effects on most types of cells and tissues.
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References in periodicals archive ?
S1P acts through five specific receptors (S1P1, S1P2, S1P3, S1P4, and S1P5) [55-57].
Tabeling et al., "Sphingosine-1-phospate receptor 4 (S1P4) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model," FASEB Journal, vol.
Lipp, "The sphingosine 1-phosphate receptor S1P4 regulates cell shape and motility via coupling to Gi and G12/13," Journal of Cellular Biochemistry, vol.
Bruni, "TGFbeta1 evokes myoblast apoptotic response via a novel signaling pathway involving S1P4 transactivation upstream of rho-kinase-2 activation," The FASEB Journal, vol.
Goetzl, "Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration," The FASEB Journal, vol.
Velaparthi et al., "Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists," Bioorganic & Medicinal Chemistry Letters, vol.