Stem cell mobilization is S1P1- and S1P3dependent [24, 25], while S1P2
receptor activation promotes BM cell retention .
Using methods of computational bioorganic chemistry, the receptor S1P2
was put into a computer simulator to test the ligand binding potential of twenty-six possible ligands at the spbingosine-1-phosphate binding site.
S1P acts through five specific receptors (S1P1, S1P2
, S1P3, S1P4, and S1P5) [55-57].
Liu et al., "The sphingosine-1-phosphate receptors S1P1, S1P2
, and S1P3 function coordinately during embryonic angiogenesis," The Journal of Biological Chemistry, vol.
Yanase et al., "Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation," Biochemical and Biophysical Research Communications, vol.
Uranbileg et al., "Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human," Scientific Reports, vol.
Kleuser, "Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2
receptor subtype," PLoS One, vol.
Park, "Activation of S1P2
receptor, a possible mechanism of inhibition of adipogenic differentiation by sphingosine 1-phosphate," Molecular Medicine Reports, vol.
Yoshioka et al., "S1P2, the G protein-coupled receptor for sphingosine-1- phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice," Cancer Research, vol.
Watterson et al., "The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation," Molecular and Cellular Biology, vol.