S100A8


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S100A8

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation, as well as other cellular processes.

Molecular pathology
Altered expression of S100A8 is associated with cystic fibrosis.
References in periodicals archive ?
S100A8 and S100A9 activate MAP kinase and NF-[kappa]B signaling pathways and trigger translocation of RAGE in human prostate cancer cells.
Abbreviations SEM: Scanning electron microscopy MPO: Myeloperoxidase Lf: Lactoferrin NGAL: Neutrophil gelatinase-associated lipocalin S100A8, S100A9: The S100 calcium-binding proteins, known also as calgranulins A and B or myeloid-related proteins MRP8 and MRP14 MMP-9: Matrix metalloproteinase 9 or gelatinase B, 92 kD MMP-8: Matrix metalloproteinase 8 TIMPs: Tissue inhibitors of metalloproteinases E2: 17[beta]-Estradiol SDS-PAGE: Sodium dodecyl sulfate polyacrylamide gel electrophoresis.
From the perspective of the whole blood transcriptome, the gene expression levels ofMMP8, ANXA1, S100A8, and S100P have been previously shown to be up-regulated during pregnancy (15, 16) and some of these immune-related genes have been demonstrated as biomarkers for pregnancy complications.
After the pre-separated plasma samples were retrieved and thawed at room temperature, the IL-6, S100A9, and S100A8 protein levels were detected by an enzyme-linked immunosorbent assay (ELISA) following the manufacturer's instructions (IL-6: eBioscience, USA; S100A8 and S100A9: CycLex, Japan).
S100A8 can be used as prognostic and diagnostic biomarker because of its overexpression observed in MHCC-97H and Huh-7 cell lines [16].
Singh, "Increased expression of TLR9 associated with pro-inflammatory S100A8 and IL-8 in diabetic wounds could lead to unresolved inflammation in type 2 diabetes mellitus (T2DM) cases with impaired wound healing," Journal of Diabetes and its Complications, vol.
In addition to activation of the prostaglandin axis, PPAR[delta] increases expression of the acute phase proteins Saal, Saa2, S100a8, and S100a9, as well as several members of the kallikrein gene family [31], all of which are elevated in [ER.sup.+] breast cancer [59, 60] and whose promoter regions contain PPREs.
Several genes including genes coding proteins associated with response to microbes and phagocytosis (S100A8, S100A10, LYZ, CD 14, CD93) and processing and presentation of antigens linked to MHC class II molecules (CD74, IFI30, HLA-DR paralogues) were found to be highly expressed in intermediate monocytes as compared to non-classical monocytes.
Calprotectin is a calcium and zinc binding protein complex formed by S100A8 and S100A9 proteins.
S100A8 (calgranulin A or migration inhibitory factor-related protein-8 (MRP-8)) and its binding partner S100A9 (calgranulin B or MRP-14) are two members of a multigenic family of cytoplasmic Ca2+-binding proteins [1].
The HGNC approved names of genes encoding for MRP8 and MRP14 are S100A8 and S100A9, respectively.