S100A7

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the  S100A7-encoded protein is unknown.
 
Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.
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References in periodicals archive ?
Novel S100A7 (psoriasin)/ S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
S100 represents a family of calcium modulated proteins which include S100A7 (psoriasin) which was identified in keratinocytes harvested from psoriatic skin.
Nuclear S100A7 is associated with poor prognosis in head and neck cancer," PLoS ONE, vol.
S100 proteins are part of the inflammatory response and a number of these proinflammatory cytokines (S100B, S100A6, S100A7, S100A1, S100A9, and S100A12) have been implicated in neurodegenerative disorders, such as AD.
On the opposite, expression of exogenous S100A7 in primary corticohippocampal neuron cultures derived from Tg2576 transgenic embryos inhibits the generation of A[beta] and promotes the activity of [alpha]-secretase [140].
A number of urinary markers are currently under investigation for early detection of SCC, including S100A7,[sup.
In preclinical mouse models of psoriasis, IMO-3100 exerted therapeutic activity by inhibiting disease-associated gene expression and cytokines, such as IL-6, IL-22, IL-17, IL-23, NLRP3 and IL-1, and proteins in the skin such as S100A7, DEFB4 and LL37.
40,56-64) A variety of other antibodies such as cytokeratin 7, 34PE12, and S100A7 are less specific and sensitive for squamous differentiation.