S100A7

S100A7

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The function of the  S100A7-encoded protein is unknown.
 
Molecular pathology
S100A7 is overexpressed in the skin lesions of psoriasis, but is not a candidate gene for familial psoriasis.
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In addition, bMECs treated with E2 show upregulated gene expression of antimicrobial molecules, such as DEFB1 (defensin beta 1), BNBD5 (bovine neutrophil beta-defensin 5), and S100A7 (psoriasin) [60].
S100A7 (psoriasin), S100A8 (calgranulin A), S100A9 (calgranulin B), and S100A12 (calgranulin C) are markedly increased in psoriasis lesions [2, 75].
Novel S100A7 (psoriasin)/ S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function.
Enerback, "Cluster analysis of S100 gene expression and genes correlating to psoriasin (S100A7) expression at different stages of breast cancer development," International Journal of Oncology, vol.
Glaser, "Differential expression and in vivo secretion of the antimicrobial peptides psoriasin (S100A7), RNase 7, human beta-defensin-2 and -3 in healthy human skin," Experimental Dermatology, vol.
S100 proteins are part of the inflammatory response and a number of these proinflammatory cytokines (S100B, S100A6, S100A7, S100A1, S100A9, and S100A12) have been implicated in neurodegenerative disorders, such as AD.
A number of urinary markers are currently under investigation for early detection of SCC, including S100A7,[sup.22] SCC antigen, BCL2, p53 drug,[sup.23] nitric oxide,[sup.24] cyclo-oxygenase-2[sup.25] and cytokeratin.[sup.26] These markers may well represent an effective and practical approach to screening high-risk patients.
The expression of human SOCS3, S100A7, IL-20, HBD-2, LL37, and HPRT-1 mRNA was evaluated in the ABI Prism SDS 7000 PCR instrument (Applied Biosystems, Branchburg, NJ), using SYBR Green PCR reagents or TaqMan PCR Master Mix.
IL-37, expressed in macrophages, epithelial cells, and effector-memory cells, likewise demonstrated an immunosuppressive role in K14-VEGF-A transgenic mice by downregulating the production of proinflammatory cytokines, such as CXCL8, IL-6, and S100A7 [56].
Vitamin D analog calcipotriol suppresses the Th17 cytokine-induced proinflammatory S100 "alarmins" psoriasin (S100A7) and koebnerisin (S100A15) in psoriasis.
S100 represents a family of calcium modulated proteins which include S100A7 (psoriasin) which was identified in keratinocytes harvested from psoriatic skin.
Psoriasin (S100A7) associates with integrin [beta]6 subunit and is required for [alpha]v[beta]6-dependent carcinoma cell invasion.