S100 proteins are part of the inflammatory response and a number of these proinflammatory cytokines (S100B, S100A6
, S100A7, S100A1, S100A9, and S100A12) have been implicated in neurodegenerative disorders, such as AD.
CacyBP protein could be interacted with S100 protein family including S100A1, S100A6
, S100A12, S100B, and S100P.
Procollagen 1 (PC1), CD10, and S100A6
are typically reactive in AFX, but those markers often stain a variety of other neoplasms.
As can be expected, these genes can be assigned to different functional groups such as cell death regulators (CASP2, ING2, MDM4, NAIP), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, P0LR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), oxidative stress response (SPATS2L, GSTT2B, NQO1), DNA maintenance and processing (BAHCC1, FANCA, H1ST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), blood coagulation (FGA, MATR3, PROCR, P1K3CG), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, T1CAM2), cytoskeletal components (BCL7A, DYNC1LI2, SEPT10, SEPT11), transport functions (ABCC1, FXYD2, S100A6
, SCNN1G, XP05), or others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
11] APP, COL14A1, ROBO1, ITGAV, COL12A1, SCARB1, SCARB2, CNTN3, MFAP4, COL24A1, THBS2 multicellular 46 AEBP1, S100A6
, HUS1, UTRN, 0,005 organismal GPM6B, POSTN, FKBP1A, ENPEP, development MYLIP, CBFB, PTK2, APP, ROBO1, CASP7, ITGAV, COL12A1, FBN2, LOX, USH2A, OLFM1, DCLK1, MLLT3, EGFL6, NRXN3, MAP1B, CHODL, ITGA2, AFF3, IGF2, SIRT1, COL5A1, CTNNBIP1, DKK3, MAN2A1, DACT1, CNTF, TMEM111, SFRP2, GRN, IRF1, SORT1, CNTN3, PSME4, COL1A1, CASQ2, MYH10 muscle organ 8 APP, AEBP1, CNTF, UTRN, CHODL, 0,008 development FKBP1A, SIRT1, MYH10 lipid 9 PTGES3, SAMD8, CYB5R1, AGPAT5, 0,026 biosynthetic C1QTNF3, LASS3, ALOX5AP, process SCARB1, ELOVL6 La interpretacion funcional mostro enriquecimiento en funciones estrechamente relacionadas con el desarrollo y adipogenesis del tejido muscular.
Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6
The researchers then narrowed the molecules down to two proteins, S100A6
and S1009, which are most likely to appear in samples from patients with cancer but are absent from the other samples.
Asi, por ejemplo, en la interaccion con las proteinas S100B o S100A6
, una puede activar la via de la cinasa PI3/AKT y la otra la via de JNK, a pesar de que los ligandos pertenecen a la misma familia y son estructuralmente identicos (14).
S100 calcium-binding protein A6 (calcyclin) Hs.
8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6
, FTH1, DHCR7 2.
In the instance of background staining, S100A6
can be a good substitute, although weak nuclear and cytoplasmic staining for S100A6
can be seen in normal/reactive pancreatic ducts.