S100A5

S100A5

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A5-encoded protein has a 20- to 100-fold higher affinity for Ca2+ than the other S100 proteins under identical conditions; it also strongly binds Zn2+ and Cu2+, which impairs the binding of Ca2+.
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References in periodicals archive ?
In addition to [Ca.sup.2+], several S100 proteins bind [Zn.sup.2+] with a wide range of affinities ([K.sub.d] = 0.1-2000 [micro]mol/L), and some (S100B and S100A5) even bind [Cu.sup.2+] ([K.sub.d] = 0.4-5 [micro]mol/L).
Brain S100A5 is a novel calcium-zinc-, and copper ion-binding protein of the EF-hand superfamily.