S100A4

S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1[alpha] to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.
Antibody Company Clone Dilution CAF phenotype-related proteins Podoplanin Abcam, Cambridge, UK 18H5 1:100 Prolyl 4-hydroxylase Abcam, Cambridge, UK Polyclonal 1:200 FAP[alpha] Abcam, Cambridge, UK Polyclonal 1:100 S100A4 Abcam, Cambridge, UK Polyclonal 1:100 PDGFR[alpha] Abcam, Cambridge, UK Polyclonal 1:100 PDGFR[beta] Abcam, Cambridge, UK Y92 1:100 NG2 Abcam, Cambridge, UK NG2 1:50 TABLE 2: Clinicopathologic characteristics of patients with phyllodes tumor.
The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers.
Hyperthermia inhibits cell proliferation and induces apoptosis: relative signaling status of P53, S100A4, and notch in heat sensitive and resistant cell lines.
They found that the protein S100A4 plays a crucial role in brain protection and repair.
Gelsolin, alfa enolaz ve S100A4 proteinleri keratokonuste farklilik gosterirler ve keratokonusun patogenezinde rol oynayabilirler.
Molecular mechanisms of Ca (2+) signaling in neurons induced by the S100A4 protein.
In the second study, S100A4 mRNA levels in blood were used to help diagnose patients with colon, rectal and gastric cancers.
There was no interference/cross-reactivity by the other 5100 proteins tested, including S100A6 and S100A4, which are highly expressed in brain tissue.
In addition, treatment led to a decrease in dermal thickness and suppression of keratinocyte peptides, including S100A4, S100A7a, and Defensin 4, compared to untreated mice.
Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma.