S100A4

S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
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References in periodicals archive ?
S100A4 is a member of the S100 protein family comprising [sup.+]20 members of small [Ca2.sup.+]-binding proteins (18).
Different forms of cancer exhibit dramatic changes in the expression of S100 proteins such as S100B, S100A2, S100A4, S100A6, and S100P.[32] For example, elevated levels of S100A4 (metastasin) are associated with poor survival rates in human breast cancer patients and have been found to induce metastasis in mouse models.
S100A4 is found in the nucleus, cytoplasm, and the extracellular space, bearing a wide range of biological functions including angiogenesis, cell survival, motility, and regulation of intercellular adhesion [6].
Eizuka et al., "Vascular Invasion and Stromal S100A4 Expression at the Invasive Front of Colorectal Cancer are Novel Determinants and Tumor Prognostic Markers," Journal of Cancer, vol.
The entire population of our cells expressed the nestin (Figure 1(a)) and S100A4 (Figure 1(b)) proteins.
In a complex with the [Ca.sup.2+]-binding protein Mts1 (S100A4), Tag7 has chemoattractant activity [22].
Mao, "Abnormal expression of EMT-related proteins, S100A4, vimentin and E-cadherin, is correlated with clinicopathological features and prognosis in HCC," Medical Oncology, vol.
DE genes Samples Upregulated Downregulated C versus Pcdhgb2 Ubd, Ttr, M [intersection] F Cxcl9, Serpina3n, versus Irg1, Odf1, Trpv4 M [intersection] A versus M F versus Ifit1, AABR06089930.1, M [intersection] C LOC100912860 Cd80, versus M Tfec, Il1rn A versus Alas2, Plac8, C3, M [intersection] C Angptl1, Bcl2a1, S100a4, versus M Cndp1 Il15ra, Ptprcap, Lgals3, Ccl2, LOC691141, Ptx3, Itgal, Pram1, Hk3, Pate4, A2m F versus Ada, Hsf5, Rn50_1_2682.1, M [intersection] A Slc16a12 Cd22 versus M Table 3: Common significant GO terms for DE genes.
demonstrated that TGF-[beta]1 expression was generally higher in COPD subjects throughout the airway wall, while p-Smad2/3 expression was associated with smoking, especially in current smoking COPD; in addition, p-Smad was related to airflow obstruction and S100A4 expression [9].
Yue et al., "Clinical significance of E-cadherin, [beta]-catenin, vimentin and S100A4 expression in completely resected squamous cell lung carcinoma," Journal of Clinical Pathology, vol.
Shen et al., "EZH2 mediates the regulation of S100A4 on E-cadherin expression and the proliferation, migration of gastric cancer cells," Hepato-Gastroenterology, vol.