S100A3

S100A3

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A3-encoded protein is highly expressed in skin and may be involved in calcium-dependent differentiation of skin and hair shaft.
References in periodicals archive ?
The three significant CpG sites are cg26842024 in KLF2 gene, cg07426848 in the S100A3 gene, and cg17589341 in the SLC14A1 gene.
Gene Product Capn3 NM_007601 Calpain 3 S100a3 NM_011310 S100 calcium binding protein A3 Camkk1 NM_018883 Calcium/calmodulin-dependent protein kinase kinase 1 Efcab4a NM_001025103 EF-hand calcium binding domain 4A alpha polypeptide 7 Pcdhb11 NM_053136 Protocadherin beta 11 Calr NM_00759 Calreticulin Gene Symbol Fold Change p-Value Capn3 +1.5 0.03 S100a3 +1.4 0.03 Camkk1 +1.2 0.01 Efcab4a +1.4 0.04 Pcdhb11 -2.2 0.004 Calr -1.2 0.04 Table 4.
Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins.
Ciaudelli award, sponsored by Croda Inc.--Takafumi Inoue, Ph.D, Ichiro Sasaki, Masahito Yamaguchi and Kenji Kizawa for their paper, "Elution of S100A3 from hair fiber: new model for hair damage emphasizing the loss of S100A3 from cuticle;"