Different forms of cancer exhibit dramatic changes in the expression of S100 proteins such as S100B, S100A2
, S100A4, S100A6, and S100P. For example, elevated levels of S100A4 (metastasin) are associated with poor survival rates in human breast cancer patients and have been found to induce metastasis in mouse models.
S100 calcium binding Cell regulation protein A2 10.
Expression of S100A2
and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids.
Mogushi et al., "Overexpression of the S100A2
protein as a prognostic marker for patients with stage II and III colorectal cancer," International Journal of Oncology, vol.
The current study focused on highlighting the number of cases of SCC of the oesophagus from 1912 to 2010, as well as confirming the presence of carcinogenic N-nitrosamines via high-performance liquid chromatography (HPLC) and the interaction of N-nitrosamines with S100A2 protein to determine the actual mechanisms of this interaction using molecular docking studies.
We proposed that the carcinogenic property of N-nitrosamines in the oesophagus may alter the expression of the S100A2 protein by changing its 3D conformation and hence its normal functioning.
The sensitivity of measurement of CLCA2 expression (64.6%) was relatively low as compared to that of measurement of p63, p40, and CK5/6 reported previously [16, 17, 33], whereas it was better than that for other SCC-specific markers, such as glypican-3 (46%), S100A2
(63%), and CD141 (46%) reported previously [16, 33].
Krug et al., "S100A2
induces metastasis in non-small cell lung cancer," Clinical Cancer Research, vol.
Keratokonuslu hastalarin bir kisminda, ucu protein sentezine etki eden CLC, DSG3, EMP3, S100A2
and SLPI genlerinin farkli disavurumlari oldugu gosterilmistir.
Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2
, S100A3 and S100A6 proteins.
Deregulation of S100 gene expression is observed in several human diseases, which has made individual S100 proteins valuable diagnostic markers for conditions such as inflammation and wound healing (S100A8, -A9, and -A12), cardiomyopathy/myocardial infarction (S100A1), classification of human tumors (S100A2
, -A4, and -A6), and in evaluating the metastatic potential/prognosis of patients (S100A2
Orntoft, "Altered expression of CLC, DSG3, EMP3, S100A2
, and SLPI in corneal epithelium from keratoconus patients," Cornea, vol.