S100A2

S100A2

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A2-encoded protein is thought to have tumour suppressor activity.

Molecular pathology
Gene rearrangements and altered expression of S100A2 have been implicated in breast cancer.
References in periodicals archive ?
The current study focused on highlighting the number of cases of SCC of the oesophagus from 1912 to 2010, as well as confirming the presence of carcinogenic N-nitrosamines via high-performance liquid chromatography (HPLC) and the interaction of N-nitrosamines with S100A2 protein to determine the actual mechanisms of this interaction using molecular docking studies.
We proposed that the carcinogenic property of N-nitrosamines in the oesophagus may alter the expression of the S100A2 protein by changing its 3D conformation and hence its normal functioning.
Quantitative molecular docking studies were performed to determine the degree of N-nitosamine-S100A2 interaction and the affinity of the N-nitrosamines for the S100A2 protein.
Molecular docking of N-nitrosamines with the S100A2 protein
The binding mode of NPYR and the S100A2 protein had an established inhibition constant with a concentration value of 247.
This confirmed the high affinity of NPYR towards the S100A2 protein.
Keratokonuslu hastalarin bir kisminda, ucu protein sentezine etki eden CLC, DSG3, EMP3, S100A2 and SLPI genlerinin farkli disavurumlari oldugu gosterilmistir.
CLC, DSG3, EMP3, S100A2 and SLPI genlerinin disavurumu keratokonuste farklidir.
Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients.
Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins.