S100A2

S100A2

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A2-encoded protein is thought to have tumour suppressor activity.

Molecular pathology
Gene rearrangements and altered expression of S100A2 have been implicated in breast cancer.
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References in periodicals archive ?
Different forms of cancer exhibit dramatic changes in the expression of S100 proteins such as S100B, S100A2, S100A4, S100A6, and S100P.[32] For example, elevated levels of S100A4 (metastasin) are associated with poor survival rates in human breast cancer patients and have been found to induce metastasis in mouse models.
Expression of S100A2 and S100P in human eccrine sweat glands and their application in differentiating secretory coil-like from duct-like structures in the 3D reconstituted eccrine sweat spheroids.
Mogushi et al., "Overexpression of the S100A2 protein as a prognostic marker for patients with stage II and III colorectal cancer," International Journal of Oncology, vol.
The current study focused on highlighting the number of cases of SCC of the oesophagus from 1912 to 2010, as well as confirming the presence of carcinogenic N-nitrosamines via high-performance liquid chromatography (HPLC) and the interaction of N-nitrosamines with S100A2 protein to determine the actual mechanisms of this interaction using molecular docking studies.
We proposed that the carcinogenic property of N-nitrosamines in the oesophagus may alter the expression of the S100A2 protein by changing its 3D conformation and hence its normal functioning.
The sensitivity of measurement of CLCA2 expression (64.6%) was relatively low as compared to that of measurement of p63, p40, and CK5/6 reported previously [16, 17, 33], whereas it was better than that for other SCC-specific markers, such as glypican-3 (46%), S100A2 (63%), and CD141 (46%) reported previously [16, 33].
Krug et al., "S100A2 induces metastasis in non-small cell lung cancer," Clinical Cancer Research, vol.
Keratokonuslu hastalarin bir kisminda, ucu protein sentezine etki eden CLC, DSG3, EMP3, S100A2 and SLPI genlerinin farkli disavurumlari oldugu gosterilmistir.
Aberrantly differentiated cells in benign pilomatrixoma reflect the normal hair follicle: immunohistochemical analysis of Ca-binding S100A2, S100A3 and S100A6 proteins.
Deregulation of S100 gene expression is observed in several human diseases, which has made individual S100 proteins valuable diagnostic markers for conditions such as inflammation and wound healing (S100A8, -A9, and -A12), cardiomyopathy/myocardial infarction (S100A1), classification of human tumors (S100A2, -A4, and -A6), and in evaluating the metastatic potential/prognosis of patients (S100A2 and -A4).
Orntoft, "Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients," Cornea, vol.