S100A13

S100A13

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A13-encoded protein plays a role in the export of proteins that lack a signal peptide, which are secreted by an alternative pathway. It is widely expressed in various tissues with high expression in thyroid gland; it is co-expressed with other family members in the nucleus and in stress fibres, suggesting a role in signal transduction.
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References in periodicals archive ?
Among them, Alpha-L-Fucosidase 1 (FUCA1) exerts immunoregulatory actions [47], Meteorin-like protein (METRL) stimulates the expression of anti-inflammatory cytokines [48], and S100 calcium-binding protein A13 (S100A13) acts as a regulator of macrophage inflammation [49].
Other factors like Glycyl-L-histidyl-L-lysine (GHK) (Swaim et al., 1996, Canapp et al., 2003), multiprotein complexes containing S100A13 protein (Prudovsky et al., 2003) and Fibronectin, a large extracellular matrix cell adhesion glycoprotein (Ahmed et al., 1999) are known to play additive roles in wound repair mechanism.
In a first step we cloned human S100B, S100Al through -A6, S100A12, and S100A13 into expression vectors for high expression in Escherichia coli and purified the recombinant proteins by ammonium sulfate precipitation, followed by [Ca.sup.2+]-dependent hydrophobic interaction, size-exclusion, and/or exchange chromatography (1, 3).