S100A12


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S100A12

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which contain 2 EF-hand calcium-binding motifs and as a group regulate cell cycle progression and differentiation and other cellular processes. The S100A12-encoded protein may be involved in calcium-dependent signal transduction pathways; its regulatory effect on cytoskeletal components may modulate neutrophil activities and trigger the release of cytokines.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Leach, "Fecal S100A12 in healthy infants and children," Disease Markers, vol.
S100A12 induces the expression of endothelial adhesion molecules, promoting leukocyte recruitment (33), neutrophil oxidative burst, degranulation and secretion (34), and pulmonary mast cell activation (35).
Qureshi et al., "Elevated circulating S100A12 associates with vascular disease and worse clinical outcome in peritoneal dialysis patients," Peritoneal Dialysis International, vol.
Utter et al., "Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease," Neurobiology of Aging, vol.
There was no relationship between fecal M2-PK and fecal S100A12 levels in the children with active CD.
Day, "S100A12: a noninvasive marker of inflammation in inflammatory bowel disease," Journal of Digestive Diseases, vol.
S100A8/A9 and S100A12 induce prothrombotic and proinflammatory responses in endothelial cells including induction of thrombospondin, chemokines, and adhesion molecules [77].
Several S100 proteins have so far been identified as DAMPs, including S100A7 [6], S100A8, S100A9, S100A12 [5, 7], and S100A15 [6].
A study in children undergoing cardiac surgery requiring CPB showed another leukocyte S100 protein, S100A12, increased postoperatively and levels were correlated with respiratory parameters, ICU and hospital length of stay [22].
In recent years, the mediators S100A12 and RAGE have drawn attention as specific markers of ALI [102].