Among the DGRs, CNTN2, KCNK1 and S100A1
were found common in frontal cortex and hippocampus datasets.
While troponin I is a well-known marker of cardiac injury, S100A1
originates in cardiomyocytes (8) and it is not clear whether its expression correlates with troponin or can be useful as a new marker of cardio-oncology.
MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1
. PLoS One 2013;8:e78684.
Donato, "Annexin V, annexin VI, S100A1
and S100B in developing and adult avian skeletal muscles," Neuroscience, vol.
Lovering et al., "S100A1
promotes action potential-initiated calcium release flux and force production in skeletal muscle," American Journal of Physiology Cell Physiology, vol.
Indeed, HMGB1 and the two S100 family proteins, S100B and S100A1
, increase the expression of the antiapoptotic protein Bcl-2, in a RAGE-dependent way, favoring neuroblastoma cell survival [17,29].
CacyBP protein could be interacted with S100 protein family including S100A1
, S100A6, S100A12, S100B, and S100P.
The partnership includes uniQure's proprietary gene therapy programme for congestive heart failure that is intended to restore the heart's ability to synthesize S100A1
, a calcium sensor and master regulator of heart function as well as the potential for target-exclusive collaboration in other disease areas.
The collaboration includes uniQure's gene therapy program for congestive heart failure that aims to restore the heart's ability to synthesize S100A1
, a calcium sensor and master regulator of heart function.
Cardiology researchers have demonstrated feasibility, the long-term therapeutic effectiveness and the safety of S100A1
gene therapy in a large animal model of heart failure under conditions approximating a clinical setting.
The panels of antibodies in various combinations included carbonic anhydrase IX, vimentin, cytokeratin 7 (CK7), CKIT, P504S, TFE3, S100A1
, CD10, EMA, INI1, PAX2, PAX8, AE1/AE3, CAM5.2, CK20, HMWCK, Melan-A, HMB-45, synaptophysin, chromogranin, and E-cadherin.
Augmentation of Cav1 channel current and action potential duration after uptake of S100A1
in sympathetic ganglion neurons.