Islam, "Genomic analysis and differential expression of HMG and S100A
family in human arthritis: upregulated expression of chemokines, IL-8 and nitric oxide by HMGB1," DNA and Cell Biology, vol.
Calprotectin, also called S100A, is a critical factor in the innate immune response to infection and has been shown to inhibit microbial growth through chelation of nutrient [Mn.sup.2+] and [Zn.sup.2+], resulting in reprogramming of the bacterial transcriptome .
Furthermore, NETs facilitate pathogen exposing to highly concentrate antimicrobial peptides and enzymes, such as MPO, neutrophil elastase, LL-37, S100A, and lactoferrin-chelating proteins .
A volume of studies has indicated DAMPs (e.g., HMGB1, S100A
calgranulin, IL-1[alpha], and IL-33) have been found in abundance in active IBD patients, suggesting the persistently and chronic inflamed intestinal mucosa may symbolize abundant DAMP resources .
Moreover, we found a differential regulation of transcripts associated with inflammatory processes in the skin (e.g., S100A
) , which are associated with an altered cellular phenotype, and enhanced expression of inflammatory mediators, for example, cytokines .
Abdrabbo et al., "Gastric cancers overexpress S100A
calcium-binding proteins," Cancer Research, vol.
For example, the RCC marker antigen and CD10 are preferentially expressed in proximal tubules and the corresponding clear cell RCC; S100A
, claudins, and kidney-specific cadherin are preferentially expressed in distal convoluted tubules and corresponding chromophobe RCC and oncocytoma.
The presentation is scheduled for Monday, June 2, 2008 from 3:30 PM - 3:45 PM in room S100a
at McCormick Place, Chicago, Illinois.
Six of the species present in the 10- to 13-kDa spectral cluster figure were identified as members of the S100A protein family, which are also derived from neutrophils.
The most readily detected and identifiable proteins in the BALF were DEFAs and S100A proteins.
Each major type of renal epithelial neoplasm is thought to be derived from a specific nephron segment, and thus, is expected to display an immunoprofile akin to that of the parental nephron segment, for examples, the RCC marker (17) and CD10 for proximal tubules (22) and the corresponding clear cell and papillary RCCs; parvalbumin, (16,23,24) S100A
, (25-(27) claudins, (28) kidney-specific cadherin for distal portion of the nephron, (29,30) and the corresponding chromophobe RCC and oncocytoma; and high-molecular-weight cytokeratins for the collecting duct and the corresponding collecting duct RCC.
, CAPL, CACY: molecular cloning and expression analysis or three calcium-binding proteins from human heart.