Schistosoma mansoni

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Schistosoma

 [shis″-, skis″to-so´mah]
a genus of trematodes, including several species parasitic in the blood of humans and domestic animals. The organisms are called schistosomes or blood flukes. Larvae (cercariae) enter the body of the host by way of the digestive tract, or through the skin from contact with contaminated water, and migrate in the blood to small blood vessels of organs of the intestinal or urinary tract; they attach themselves to the blood vessel walls and mature and reproduce. The intermediate hosts are snails of various species.
The life cycle of Schistosoma. From Mahon and Manuselis, 2000.
Schistosoma haemato´bium a species endemic in North, Central, and West Africa and the Middle East; the organisms are found in the venules of the urinary bladder wall, and eggs may be isolated from the urine.
Schistosoma japo´nicum a species geographically confined to China, Japan, and nearby countries; found chiefly in the venules of the intestine.
Schistosoma manso´ni a species widely distributed in Africa and parts of South America; the organisms are found in the host's mesenteric veins, and eggs may be found in the feces.

Schis·to·so·ma man·so·ni

a common species of trematode characterized by large eggs with a strong lateral spine and transmitted by planorbid snails of the genus Biomphalaria; causes schistosomiasis mansoni in humans in Africa, parts of the Middle East, South America, and certain Caribbean islands.

Schis·to·so·ma man·so·ni

(skis'tō-sō'mă man-sō'nī)
A common species of trematodes characterized by large eggs with a strong lateral spine and transmitted by planorbid snails of the genus Biomphalaria; causes schistosomiasis mansoni.

Manson,

Sir Patrick, English authority on tropical medicine, 1844-1922.
Schistosoma mansoni - a disease-causing parasite transmitted by snails.
Mansonella - a genus of filaria, widely distributed in tropical Africa and South America.
Mansonia - a genus of brown or black medium-sized mosquitoes.
Manson disease - Synonym(s): Schistosoma mansoni
Manson eye worm - a widely distributed spiruroid nematode parasite of fowl. Synonym(s): Oxyspirura mansoni
Manson pyosis - obsolete term for a superficial pyogenic infection. Synonym(s): pemphigus contagiosus
Manson schistosomiasis - Synonym(s): schistosomiasis mansoni
Manson syndrome - pulmonary obliterative arteriolitis.
Oxyspirura mansoni - Synonym(s): Manson eye worm
schistosomiasis mansoni - infection with Schistosoma mansoni. Synonym(s): intestinal schistosomiasis; Manson disease; Manson schistosomiasis
References in periodicals archive ?
Mean prevalence of intestinal schistosomiasis, calculated by detection of S. mansoni circulating cathodic antigen (CCA) on urine dipstick testing, was 34.3% (95% CI 27.9-41.3); prevalence rates by school were Samama, 46.7% (95% CI 36.7-56.7); Mchoka, 25.0% (95% CI 15.0-36.7); and Palm Beach, 9.1% (95% CI 0.0-22.7).
The hepatosplenic form of S. mansoni infection (SMI) is due to egg-induced inflammation and fibrosis in liver presinusoidal portal areas, leading to portal hypertension, esophageal varices formation and digestive bleeding.
The detection of S. mansoni egg or intestinal Schistosoma eggs in stool sample was conducted according to the method as flows [16]: Firstly a drop of fresh physiological saline was placed on slide using a piece of stick, a small amount of specimen (about 2 mg), was mixed to make smooth thin preparation, then covered with cover glass and examined microscopically using 10x and 40x objectives.
S. mansoni, one of the three major Schistosoma species responsible for causing human schistosomiasis worldwide, is endemic in much of the sub-Saharan Africa, Madagascar, the Caribbean area, and parts of South America and causes intestinal schistosomiasis [3].
In early 1990, some researchers found that animals infected with Schistosoma mansoni could produce antibodies that was specific to one protein of HIV, the regulatory protein virion infectivity factor (VIF), and the VIF could identify a 170 kDa peptide of S. mansoni [12].
Infection with S. mansoni can also cause hepatomegaly, splenomegaly, fever, and/or anemia (5).
The polymerase chain reaction (PCR) assays for amplification of the Sm1-7 repeated sequence of S. mansoni [1] and the low stringency-PCR (LS-PCR) for amplification of tandem DNA region of S.
Among many identified species of Biomphalaria, Biomphalaria alexandrina is the intermediate host of S. mansoni in Egypt (Morgan et al., 2001; Lotfy, DeJong, Black, & Loker, 2005; Abou-El-Naga, El-Nassery, Allam, Shaat, & Mady, 2011; Mohamed, El-Din, Mohamed, & Habib, 2012).
Also, this present work describes, for the first time, the S. mansoni ATP diphosphohydrolase inhibitory activity of cardamonin, as well as, its molecular docking with S.