What happens to cohesin during DNA replication in S-phase
, so that it establishes cohesion between newly synthesized sister chromatids?
Project title: Stablization of cyclin D1 in S-phase
as a novel therapeutic approach for mantle cell lymphoma and multiple myeloma.
Coagulin-L inhibited mitotic clonal expansion (MCE) by delayed entry in G1 to S phase transition and S-phase
The threshold amount needed for G1 cells to progress into the S phase has been defined as the minimum nRNA content of S-phase
nuclei determined from plots of nRNA and DNA fluorescence measured by flow cytometry (Darzynkiewicz et al.
Results: Our results show that YQFS significantly inhibits colorectal cancer cell proliferation and induces apoptosis and cell cycle arrest at the G1- and S-phase
in HCT-116 cells.
Earlier we reported higher frequency of aneuploidy and higher S-phase
fraction in oral tumours that was related to advanced clinical stage, lymph node metastasis, poor histological differentiation and early recurrence (13).
Conclusion: It was shown that heparin expands the proliferation of lymphoblasts by increasing the transition to G2/M and S phases and the S-phase
cytotoxics, such as Pfizer's irinotecan or Eli Lilly's gemcitabine, are capable of killing virtually all cells that are in the S-Phase
, however, less than one third of cancer cells are typically in the S-Phase
during chemotherapy," explains Mark Zamoyski, the inventor.
Some areas described are remanufacturing and automatic surface engineering technology, plasma transferred arc powder surfacing technology of thrust face, cerium- phytic acid passivation treatment on galvanized steel, supersaturated surface engineering S-phase
materials, and preparation of epoxy modified organosilicone high-temperature resistance coatings.
p27 is a key regulator of G1 to S-phase
After only 24 hr of treatment, we observed significant increases in the percentage of cells in the S-phase
Certain conventional chemotherapies, such as the antimetabolite gemcitabine, exert their anticancer activity at the S-phase
of the cell cycle.