S-adenosyl-l-methionine


Also found in: Acronyms.

S-adenosyl-l-methionine (SAM, AdoMet, SAM-e),

(a-den'ō-sil'me-thī'ō-nēn),
[0] A nutraceutical with antioxidative stress effect; may be used in management of liver disease; is a precursor of cysteine. In human medicine, may be used to scavenge free radicals associated with toxic insults to liver (e.g., alcohol, infection). During liver-function compromise, the resident enzyme system that generates SAM-e endogenously is compromised.
Synonym(s): active methionine
References in periodicals archive ?
S-adenosyl-L-methionine in Sjogren's syndrome and fibromyalgia.
Specific contribution of methionine and choline in nutritional nonalcoholic steato-hepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione.
S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine.
Electrophysiological neuroimaging of the central effects of S-adenosyl-L-methionine by mapping of electroencephalograms and event-related potentials and low-resolution brain electromagnetic tomography.
TPMT activity was measured in isolated erythrocytes (see below), after lysis with four volumes of ice-cold water, by an established HPLC procedure (9) based on the conversion of 6-mercaptopurine (pH 7.5 and 37 [degrees]C) to 6-MMP with S-adenosyl-L-methionine as the methyl donor.
SAMe, short for S-adenosylmethionine (also written S-adenosyl-L-methionine), until recently has been available only in Europe as the pharmaceutical preparation ademetionine.
(8) Baldessarini RJ: Neuropharmacology of S-adenosyl-L-methionine. Am J Med 83 (suppl 5A):95-103.
A randomised controlled trial of ursodeoxycholic acid and S-adenosyl-l-methionine in the treatment of gestational cholestasis.
S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease.
Hcy methyltransferase [S-adenosyl-L-methionine: L-Hcy S-methyltransferase] catalyzes the direct transfer of the methyl group of either S-adenosyl-L-methionine or S-methyl-L-methionine (L-methionine methylsulfonium) to Hcy.
The methyl donor is S-adenosyl-L-methionine (AdoMet), which is formed from adenosine triphosphate (ATP) and methionine.
(3) Nonstandard abbreviations: tHcy, total homocysteine; SAH, S-adenosyl-L-homocysteine; SAHase, SAH hydrolase; SAM, S-adenosyl-L-methionine; BSA, bovine serum albumin; DTT, dithiothreitol; Adoase, adenosine deaminase; HRP, horseradish peroxidase.