S-adenosyl-l-homocysteine


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S-a·den·o·syl-l-ho·mo·cys·te·ine

(a-den'ō-sil-hō-mō-sis'te-ēn),
Compound formed by the demethylation of S-adenosyl-l-methionine; produced by many methyltransferases.
References in periodicals archive ?
Methyl-Cbl, methyl- cobalamin; SAH, S-adenosyl-L-homocysteine; X, methyl acceptor; C[H.sub.3]-X, methylated product; Pi, phosphate; PPi, pyrophosphate.
An Adolescent with Increased Plasma Methylmalonic Acid and Total Homocysteine
The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols.
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
After donation of the activated methyl group to an acceptor, AdoMet is converted into total Hcy by formation of S-adenosyl-L-homocysteine (AdoHcy) (10).
Effect of L-dopa therapy on plasma homocysteine levels and, consequently, on carotid intima-media thickness in Parkinson's disease patients/Parkinson hastalarinda L-dopa tedavisinin, plazma homosistein duzeyleri ve bununla iliskili karotis intima-media kalinliklari uzerine olan etkisi
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
Homocysteine, HIV, and Heart Disease
D,L-Homocysteine and S-adenosyl-l-homocysteine hydrolase from rabbit erythrocytes were obtained from Sigma, and Tris base was obtained from Sigma-Aldrich.
The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine.
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatographymass spectrometry
Both methods are based on enzymatic conversion of homocysteine to S-adenosyl-L-homocysteine, which is subsequently detected by a competitive immunoassay.
Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveys
This assay involves the initial reduction of Hcy, mixed-disulfide, and protein-bound Hcy to free Hcy with dithiothreitol, followed by conversion to S-adenosyl-L-homocysteine (SAH) by bovine SAH hydrolase and excess adenosine.
Agreement among four homocysteine assays and results in patients with coronary atherosclerosis and controls
Both assays are based on enzymatic conversion of Hcy to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (SAHase; EC 3.3.1.1), followed by quantification of SAH in a competitive immunoassay with the use of a monoclonal anti-SAH antibody.
Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer
The "Abbott Homocysteine (HCY) assay" is a fluorescence polarization immunoassay based on the highly selective enzymatic conversion of homocysteine to S-adenosyl-L-homocysteine, which is then recognized by a monoclonal antibody (2).
Method comparison for total plasma homocysteine between the Abbott IMx analyzer and an HPLC assay with internal standardization
This assay is based on enzymatic conversion of tHcy (after reduction and release of endogenous homocysteine from proteins and/or disulfides) to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (EC 3.3.1.1), followed by quantification of SAH in a competitive immunoassay with use of a monoclonal antibody against SAH.
Determination of total homocysteine
The method is based on enzymatic conversion of Hcy to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (SAHase; EC 3.3.1.1), followed by quantification of SAH in a competitive immunoassay with use of a monoclonal anti-SAH antibody [5].
Enzyme conversion immunoassay for determining total homocysteine in plasma or serum
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