S-adenosyl-l-homocysteine


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S-a·den·o·syl-l-ho·mo·cys·te·ine

(a-den'ō-sil-hō-mō-sis'te-ēn),
Compound formed by the demethylation of S-adenosyl-l-methionine; produced by many methyltransferases.
References in periodicals archive ?
The presence of caffeic acid or chlorogenic acid inhibited DNA methylation predominantly through a non-competitive mechanism, and this inhibition was largely due to the increased formation of S-adenosyl-L-homocysteine (SAH, a potent inhibitor of DNA methylation), resulting from the catechol-O-methyltransferase (COMT)-mediated O-methylation of these dietary catechols.
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
After donation of the activated methyl group to an acceptor, AdoMet is converted into total Hcy by formation of S-adenosyl-L-homocysteine (AdoHcy) (10).
Effect of L-dopa therapy on plasma homocysteine levels and, consequently, on carotid intima-media thickness in Parkinson's disease patients/Parkinson hastalarinda L-dopa tedavisinin, plazma homosistein duzeyleri ve bununla iliskili karotis intima-media kalinliklari uzerine olan etkisi
D,L-Homocysteine and S-adenosyl-l-homocysteine hydrolase from rabbit erythrocytes were obtained from Sigma, and Tris base was obtained from Sigma-Aldrich.
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatographymass spectrometry
Synthesis and antiviral activity of some new S-adenosyl-L-homocysteine derivatives.
Homocysteine, HIV, and Heart Disease
The IMMULITE 2000 performs an on-line one-cycle sample pretreatment of patient plasma or serum with S-adenosyl-L-homocysteine (SAH) hydrolase and dithiothreitol (DTT) solution in a reaction tube containing no bead.
Diagnostic Products Corporation Releases New Diagnostic Test for Risk Assessment of Heart Disease
Both methods are based on enzymatic conversion of homocysteine to S-adenosyl-L-homocysteine, which is subsequently detected by a competitive immunoassay.
Interlaboratory variation of plasma total homocysteine measurements: results of three successive homocysteine proficiency testing surveys
This assay involves the initial reduction of Hcy, mixed-disulfide, and protein-bound Hcy to free Hcy with dithiothreitol, followed by conversion to S-adenosyl-L-homocysteine (SAH) by bovine SAH hydrolase and excess adenosine.
Agreement among four homocysteine assays and results in patients with coronary atherosclerosis and controls
Both assays are based on enzymatic conversion of Hcy to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (SAHase; EC 3.
Fully automated measurement of total homocysteine in plasma and serum on the Abbott IMx analyzer
The "Abbott Homocysteine (HCY) assay" is a fluorescence polarization immunoassay based on the highly selective enzymatic conversion of homocysteine to S-adenosyl-L-homocysteine, which is then recognized by a monoclonal antibody (2).
Method comparison for total plasma homocysteine between the Abbott IMx analyzer and an HPLC assay with internal standardization
This assay is based on enzymatic conversion of tHcy (after reduction and release of endogenous homocysteine from proteins and/or disulfides) to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (EC 3.
Determination of total homocysteine
The method is based on enzymatic conversion of Hcy to S-adenosyl-L-homocysteine (SAH) by the action of SAH hydrolase (SAHase; EC 3.
Enzyme conversion immunoassay for determining total homocysteine in plasma or serum
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