Nonstandard abbreviations: AD, Alzheimer disease; PD, Parkinson disease; tHcy, total homocysteine; HHCY, hyperhomocysteinemia; L-dopa, L-3,4-dihydroxyphenylalanine; COMT, catechol-O-methyltransferase; SAM, S-adenosyl methionine
; SAH, S-adenosyl homocysteine; APP, amyloid-[beta] precursor protein; ER, endoplasmic reticulum; MMA, methylmalonic acid; UPDRS, Unified Parkinson's Disease Rating Scale; MMSE, Mini-Mental Status Examination; PLP, pyridoxal-5-phosphate; holoTC, holotranscobalamin; MAO, monoamine oxidase; PCK, protein kinase C; PIMT, isoaspartyl methyl transferase; MAP, mitogen-activated protein; UPS, ubiquitin proteasome system.
Acupuncture, biofeedback, and S-adenosyl methionine
(SAMe) have been shown to have some efficacy in the treatment of fibromyalgia in randomized controlled trials.
The pill, official name S-adenosyl methionine
, is a naturally-occurring compound found in human tissue and organs.
Specific neuronal support supplements include ingredients such as S-adenosyl methionine
(SAMe), ginkgo biloba, phosphatidylserine, and apoaequorin.
2 S-Adenosyl Methionine
(SAMe) This chemical is produced naturally by the body and can also be manufactured in the laboratory.
The company will use proceeds to advance the clinical development of its formulations of s-adenosyl methionine
(SAMe) to clinical proof of concept.
(SAMe) augmentation in major depressive disorder.
The methyl group transfer (Figure 2) depends on the activation of methionine to S-adenosyl methionine
, which transfers its methyl group to an acceptor for the synthesis of various substances such as creatine, carnitine, phosphatidylcholine and epinephrine (Stryer, 1988; Kidd et al., 1997).
(SAM)  is generated from methionine metabolism and constitutes a very important methyl donor in the central nervous system.
MGH researchers have found that an over-the-counter supplement called S-Adenosyl Methionine
(SAMe), when used in conjunction with traditional antidepressant treatment, may help people with treatment-resistant depression improve and even recover from their symptoms.