S100

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S100

An acidic, calcium-binding protein characterized by its partial solubility in saturated ammonium sulfate; stains for S100 are used in the differential diagnosis of melanomas, which are commonly positive for S100.

S100A1

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells, and involved in regulating cell cycle progression and differentiation and other intracellular activities.

S100

An acidic, calcium-binding protein characterized by its partial solubility in saturated ammonium sulfate; stains for S100 are used in the differential diagnosis of melanomas, which are commonly positive for S100.
References in periodicals archive ?
Immunocytochemical evaluation with HMB-45 and S-100 resulted in positive staining pattern.
According to Schmitt and Bacchi,[2] S-100 protein is also useful as a tumor marker in diagnostic immunocytochemistry.
MDA/Schiebel is promoting the Schiebel S-100 CAMCOPTER for the ISTAR role, while QinetiQ/UMS Skeldar is proposing the Skeldar V-200b UAS.
MDA's UAS service will use a fleet of Schiebel CAMCOPTER S-100 rotary-wing unmanned aircraft to provide surveillance information.
Immunohistochemistry was positive for vimentin and synaptophysin [Figure 2] while negative for pan-Cytokeratin (panCK), P-40, S-100, epithelial membrane antigen (EMA), chromogranin, melan-A, desmin, smooth muscle actin (SMA), neuron-specific enolase, CD99, CD56, CD20, CD45, and glial fibrillary acid protein (GFAP), thus confirming ESMC.
Immunohistochemistry revealed S-100 protein, which was diffusely and strongly positive.
It is important to note that the tumour stained negative for myogenin, myoD1, des-min, S-100, nuclear beta-catenin, and MUC4.
Immunohistochemical (IHC) stains were positive for CD68, S-100 and negative for CD31, which were consistent with MSP (figures 1D, 2A, and 2B).
Diffuse expression of S-100 protein was observed with immunohistochemical staining, and Ki-67 proliferation index was observed around 5% at the highest level (Figure 2).
Microscopic pathology confirmed squamous mucosa with underlying large polyhedral cells containing granular acidophilic cytoplasm as well as small hyperchromatic nuclei, staining negative for S-100 immunohistochemistry, with extension to the excisional base of the lesion.
Immunohistochemistry for S-100 was performed as previously described [15].